Mutations of the retinoblastoma tumour suppressor gene (RB1) or components regulating
the RB pathway have been identified in almost every human malignancy. The E2F …

During tumour development cells sustain mutations that disrupt normal mechanisms
controlling proliferation. Remarkably, the Rb–E2f and MDM2–p53 pathways are both …

Recently, the long non-coding RNA (lncRNA) NEAT1 has been identified as an oncogenic
gene in multiple cancer types and elevated expression of NEAT1 was tightly linked to …

Androgen receptor (AR) plays a central role in prostate cancer, and most patients respond to
androgen deprivation therapies, but they invariably relapse with a more aggressive prostate …

Abstract The E2 factor (E2F) family of transcription factors are downstream targets of the
retinoblastoma protein. E2F factors have been known for several years to be important …

New predictive markers for managing prostate cancer are urgently required because of the
highly variable natural history of this disease. At the time of diagnosis, Gleason score …

The childhood eye cancer retinoblastoma is initiated by the loss of both alleles of the
prototypic tumor suppressor gene, RB1. However, a large number of cytogenetic and …

Long non-coding RNA (lncRNA) X inactivate-specific transcript (XIST) has been verified as
an oncogenic gene in several human malignant tumors, and its dysregulation was closed …

Background Although an increasing number of histone demethylases have been identified
and biochemically characterized, their biological functions largely remain uncharacterized …

Enhancer of zeste homologue 2 (EZH2), a member of the polycomb group protein family,
plays a crucial role in the regulation of embryonic development and has been associated …