Phosphoinositides play a crucial role in regulating many cellular functions, such as actin
dynamics, signaling, intracellular trafficking, membrane dynamics, and cell–matrix adhesion …

Uveal melanoma (UM) is the most frequently found primary intraocular tumor, although it
accounts for only 5% of all melanomas. Despite novel systemic therapies, patient survival …

The cellular microenvironment plays a critical role in cell differentiation, proliferation,
migration, and homeostasis. Recent studies have shown the importance of substrate …

Protein tyrosine phosphatases (PTPs) superfamily catalyzes tyrosine de‐phosphorylation
which affects a myriad of cellular processes. Imbalance in signal pathways mediated by …

Purpose: Uveal melanoma (UM) is a rare disease with a high mortality, and new therapeutic
options are being investigated. Preferentially Expressed Antigen in Melanoma (PRAME) is a …

Melanocytes, replenished throughout life by melanocyte stem cells (MSCs), play a critical
role in pigmentation and melanoma. Here, we reveal a function for the metastasis …

Uveal melanoma (UM) is the most common and aggressive primary intraocular tumor in
adults. UM is classified as a malignant tumor with a strong tendency of metastasis, which …

Introduction Phosphatase of regenerating liver (PRL) family proteins, also known as protein
tyrosine phosphatase 4A (PTP4A), have been implicated in many types of cancers. The PRL …

Metastatic breast cancer is characterized by high mortality and limited therapeutic target.
During tumor metastasis, cytoskeletal reorganization is one of the key steps in the migration …

Simple Summary Targeting oncogenic protein tyrosine phosphatases (PTPs) with specific
pharmacological approaches has been considered for a long time a hard challenge, earning …