Deconstructing repression: evolving models of co-repressor action
A crucial aspect of development, homeostasis and prevention of disease is the strict
maintenance of patterns of gene repression. Gene repression is largely achieved by the …
maintenance of patterns of gene repression. Gene repression is largely achieved by the …
Emerging roles of the corepressors NCoR1 and SMRT in homeostasis
A Mottis, L Mouchiroud, J Auwerx - Genes & development, 2013 - genesdev.cshlp.org
Epigenetic regulation of gene expression is strongly influenced by the accessibility of
nucleosomal DNA or the state of chromatin compaction. In this context, coregulators …
nucleosomal DNA or the state of chromatin compaction. In this context, coregulators …
[HTML][HTML] DGAT enzymes are required for triacylglycerol synthesis and lipid droplets in adipocytes [S]
CA Harris, JT Haas, RS Streeper, SJ Stone… - Journal of lipid …, 2011 - ASBMB
The total contribution of the acyl CoA: diacylglycerol acyltransferase (DGAT) enzymes,
DGAT1 and DGAT2, to mammalian triacylglycerol (TG) synthesis has not been determined …
DGAT1 and DGAT2, to mammalian triacylglycerol (TG) synthesis has not been determined …
[HTML][HTML] A PPARγ–FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis
Although feast and famine cycles illustrate that remodelling of adipose tissue in response to
fluctuations in nutrient availability is essential for maintaining metabolic homeostasis, the …
fluctuations in nutrient availability is essential for maintaining metabolic homeostasis, the …
[HTML][HTML] Deacetylase-independent function of HDAC3 in transcription and metabolism requires nuclear receptor corepressor
Histone deacetylases (HDACs) are believed to regulate gene transcription by catalyzing
deacetylation reactions. HDAC3 depletion in mouse liver upregulates lipogenic genes and …
deacetylation reactions. HDAC3 depletion in mouse liver upregulates lipogenic genes and …
[HTML][HTML] NCoR1 is a conserved physiological modulator of muscle mass and oxidative function
Transcriptional coregulators control the activity of many transcription factors and are thought
to have wide-ranging effects on gene expression patterns. We show here that muscle …
to have wide-ranging effects on gene expression patterns. We show here that muscle …
Nuclear receptor co-repressors are required for the histone-deacetylase activity of HDAC3 in vivo
Abstract Histone deacetylase 3 (HDAC3) is an epigenome-modifying enzyme that is
required for normal mouse development and tissue-specific functions. In vitro, HDAC3 …
required for normal mouse development and tissue-specific functions. In vitro, HDAC3 …
New targets to treat obesity and the metabolic syndrome
Metabolic syndrome (MetS) is a cluster ofassociated metabolic traits that collectively confer
unsurpassed risk for development of cardiovascular disease (CVD) and type 2 diabetes …
unsurpassed risk for development of cardiovascular disease (CVD) and type 2 diabetes …
A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor
A Le Maire, C Teyssier, C Erb, M Grimaldi… - Nature structural & …, 2010 - nature.com
In the absence of ligand, some nuclear receptors, including retinoic acid receptor (RAR), act
as transcriptional repressors by recruiting corepressor complexes to target genes. This …
as transcriptional repressors by recruiting corepressor complexes to target genes. This …
[HTML][HTML] Imaging fibrosis and separating collagens using second harmonic generation and phasor approach to fluorescence lifetime imaging
In this paper we have used second harmonic generation (SHG) and phasor approach to
auto fluorescence lifetime imaging (FLIM) to obtain fingerprints of different collagens and …
auto fluorescence lifetime imaging (FLIM) to obtain fingerprints of different collagens and …