The cochlea, a coiled structure located in the ventral region of the inner ear, acts as the
primary structure for the perception of sound. Along the length of the cochlear spiral is the …

Hearing loss is the most common form of sensory impairment in humans and affects more
than 40 million people in the United States alone. No drug-based therapy has been …

Mammalian hearing requires the development of the organ of Corti, a sensory epithelium
comprising unique cell types. The limited number of each of these cell types, combined with …

Hair cells of the inner ear are essential for hearing and balance. As a consequence,
pathogenic variants in genes specifically expressed in hair cells often cause hereditary …

During embryonic development, hierarchical cascades of transcription factors interact with
lineage-specific chromatin structures to control the sequential steps in the differentiation of …

Mammalian hair cells do not functionally regenerate in adulthood but can regenerate at
embryonic and neonatal stages in mice by direct transdifferentiation of neighboring …

Reprogramming of the cochlea with hair-cell-specific transcription factors such as ATOH1
has been proposed as a potential therapeutic strategy for hearing loss. ATOH1 expression …

The mechanoreceptive sensory hair cells in the inner ear are selectively vulnerable to
numerous genetic and environmental insults. In mammals, hair cells lack regenerative …

The activation of cochlear progenitor cells is a promising approach for hair cell (HC)
regeneration and hearing recovery. The mechanisms underlying the initiation of proliferation …

Cochlear hair cells (HCs) in the inner ear are responsible for sound detection. For HC fate
specification, the master transcription factor Atoh1 is both necessary and sufficient. Atoh1 …