Oxidative stress (OxS) is considered a major factor in the pathophysiology of inflammatory
chronic liver diseases, including non-alcoholic liver disease (NAFLD). Chronic impairment of …

Activated hepatic stellate cells (HSCs) and myofibroblasts are the main producers of
extracellular matrix (ECM) proteins that form the fibrotic tissue that leads to hepatic fibrosis …

Mitochondrial DNA copy number (mtDNA-CN) is a biomarker of mitochondrial function and
levels of mtDNA-CN have been reproducibly associated with overall mortality and a number …

A complex antioxidant system has been developed in mammals to relieve oxidative stress.
However, excessive reactive species derived from oxygen and nitrogen may still lead to …

Oxidative stress has been considered a key causing factor of liver damage induced by a
variety of agents, including alcohol, drugs, viral infections, environmental pollutants and …

The largest surface of the human body exposed to the external environment is the gut. At this
level, the intestinal barrier includes luminal microbes, the mucin layer, gastrointestinal …

Metallic nanoparticles (MNPs) are new engineering materials with broad prospects for
biomedical applications; thus, their biosafety has drawn great concern. The liver is the main …

Eggplant is a vegetable crop that is grown around the world and can provide significant
nutritive benefits thanks to its abundance of vitamins, phenolics and antioxidants. In addition …

Simple Summary A large number of studies report that medicinal herbs and many food
ingredients protect against the development of liver disease because they possess …

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease
worldwide. The intricate NAFLD pathogenesis is summarized by the multiple-hits …