Lipoprotein (a) in atherosclerotic diseases: from pathophysiology to diagnosis and treatment

S Lampsas, M Xenou, E Oikonomou, P Pantelidis… - Molecules, 2023 - mdpi.com
Lipoprotein (a)(Lp (a)) is a low-density lipoprotein (LDL) cholesterol-like particle bound to
apolipoprotein (a). Increased Lp (a) levels are an independent, heritable causal risk factor …

[HTML][HTML] Cellular translocation and secretion of sialidases

MA Aljohani, H Sasaki, XL Sun - Journal of Biological Chemistry, 2024 - Elsevier
Sialidases (or neuraminidases) catalyze the hydrolysis of sialic acid (Sia)-containing
molecules, mostly the removal of the terminal Sia on glycans (desialylation) of either …

The association of lipoprotein (a) and circulating monocyte subsets with severe coronary atherosclerosis

OI Afanasieva, AY Filatova, TI Arefieva… - Journal of …, 2021 - mdpi.com
Background and aims: Chronic inflammation associated with the uncontrolled activation of
innate and acquired immunity plays a fundamental role in all stages of atherogenesis …

The known unknowns of apolipoprotein glycosylation in health and disease

SP Subramanian, RL Gundry - Iscience, 2022 - cell.com
Apolipoproteins, the protein component of lipoproteins, play an important role in lipid
transport, lipoprotein assembly, and receptor recognition. Apolipoproteins are glycosylated …

Apolipoprotein (a), an enigmatic anti-angiogenic glycoprotein in human plasma: A curse or cure?

V Kalaivani, A Jaleel - Pharmacological research, 2020 - Elsevier
Angiogenesis is a finely co-ordinated, multi-step developmental process of the new vascular
structure. Even though angiogenesis is regularly occurring in physiological events such as …

Lipoprotein (a) and Immunity

OI Afanasieva, TI Arefieva, MV Ezhov, SN Pokrovsky - Lipoprotein (a), 2023 - Springer
Abstract Elevated lipoprotein (a)[Lp (a)] is a valuable risk factor for development of
atherosclerotic cardiovascular diseases (ASCVD). Within this chapter, we discuss the …

Trans-sialidase associated with atherosclerosis: defining the identity of a key enzyme involved in the pathology

VY Glanz, VA Myasoedova, AV Grechko… - Current Drug …, 2019 - ingentaconnect.com
Atherosclerosis is associated with the increased trans-sialidase activity, which can be
detected in the blood plasma of atherosclerosis patients. The likely involvement in the …

Integration of Web-Based Tools to Visualize, Integrate, and Interpret Glycogene Expression and Glycomics Data

SP Subramanian, RL Gundry - Protein Bioinformatics, 2024 - Springer
Glycosylation is the most abundant and diverse post-translational modification occurring on
proteins. Glycans play important roles in modulating cell adhesion, growth, development …

A low-molecular-weight phenotype of apolipoprotein (a) as a factor provoking accumulation of cholesterol by THP-1 monocyte-like cells

OI Afanas' eva, EB Vikhrova, OA Razova… - Bulletin of Experimental …, 2019 - Springer
Increased concentration of lipoprotein (a) is a risk factor of coronary heart disease.
lipoprotein (a) consists of LDL-like and highly polymorphic apolipoprotein (a). Here we …

[HTML][HTML] Possible molecular basis for macromolecular antigen attachment to host cells: their immune complex with plasma antibodies have unoccupied binding sites …

G George, SK Chellappan, M Geetha… - AIMS Molecular …, 2017 - aimspress.com
Macromolecules such as lipoprotein (a) and antigens of Streptococcus mutans that cause
dental infections accumulate in perivascular cells in inflammatory vascular disorders though …