Cancer has become known as a complex and systematic disease on macroscopic,
mesoscopic and microscopic scales. Systems biology employs state-of-the-art …

Tumor cells play a central role in multiple processes associated with cancer progression.
They continuously interact with surrounding cells and the extracellular matrix, displaying …

BioModels is a reference repository hosting mathematical models that describe the dynamic
interactions of biological components at various scales. The resource provides access to …

An efficient method that assists in the re-parametrization of structurally unidentifiable models
is introduced. It significantly reduces computational demand by combining numerical and …

This work presents a new framework for a competitive evolutionary game between
monoclonal antibodies and signalling pathways in oesophageal cancer. The framework is …

Designing maximally selective ligands that act on individual drug targets with high binding
affinity has been the central dogma of drug discovery and development for the past two …

Background Lung cancer is a leading cause of cancer-related death worldwide and is the
most commonly diagnosed cancer. Like other cancers, it is a complex and highly …

Counterfactual inference is a useful tool for comparing outcomes of interventions on
complex systems. It requires us to represent the system in form of a structural causal model …

This study presents a new framework for obtaining personalized optimal treatment strategies
targeting aberrant signaling pathways in esophageal cancer, such as the epidermal growth …

Отсутствие достаточно полного качественного и количественного описания поведения
температурных полей в различных органах человека, как при наличии патологических …