Acute liver failure is a rare and severe consequence of abrupt hepatocyte injury, and can
evolve over days or weeks to a lethal outcome. A variety of insults to liver cells result in a …

The present version of the American Association for the Study of Liver Diseases (AASLD)
Position Paper represents a thorough overhaul from the previous version of 2005. In …

The first human orthotopic liver transplantation (LT) in Europe was performed by Sir Roy
Calne in Cambridge in 1968 [1], only one year after the first successful human liver …

Our understanding of the natural history of hepatitis B virus (HBV) infection and the potential
for therapy of the resultant disease is continuously improving. New data have become …

Background: Acute liver failure (ALF) is a rare syndrome of severe, rapid-onset hepatic
dysfunction—without prior advanced liver disease—that is associated with high morbidity …

Objectives: To develop evidence-based recommendations for clinicians caring for adults
with acute or acute on chronic liver failure in the ICU. Design: The guideline panel …

Despite the tremendous hurdles presented by the complexity of the liver's structure and
function, advances in liver physiology, stem cell biology and reprogramming, and the …

Abstract The Asian Pacific Association for the Study of the Liver (APASL) set up a working
party on acute-on-chronic liver failure (ACLF) in 2004, with a mandate to develop consensus …

Our understanding of the natural history of hepatitis B virus (HBV) infection and the potential
for therapy of the resultant disease has improved. Several new and effective antiviral agents …

Women more commonly present with acute liver failure, autoimmune hepatitis, benign liver
lesions, primary biliary cirrhosis, and toxin-mediated hepatotoxicity. Women less commonly …