The ability to quantify DNA, RNA, and protein variations at the single cell level has
revolutionized our understanding of cellular heterogeneity within tissues. Via such analyses …

Abstract Perinatal hypoxic‐ischemic (HI)‐related brain injury is an important cause of
morbidity and long‐standing disability in newborns. The only currently approved therapeutic …

Impaired blood-brain barrier function represents an important component of hypoxic-
ischemic brain injury in the perinatal period. Proinflammatory cytokines could contribute to …

Successful neuroprotection is only possible with contemporary microvascular protection.
The prevention of disease-induced vascular modifications that accelerate brain damage …

Acquired brain injuries due to trauma damage the cortical vasculature, which in turn impairs
blood flow to injured tissues. There are reports of vascular morphological recovery following …

Central nervous system homeostasis is maintained by cellular barriers that protect the brain
from external environmental changes and protect the CNS from harmful molecules and …

Background Exposure to inflammation during pregnancy can predispose to brain injury in
premature infants. In the present study, we investigated the effects of prolonged exposure to …

Exposure to hypoxic-ischemic (HI) insults in newborns can predispose them to severe
neurological sequela. The mechanisms underlying HI-related brain injury have not been …

Microvasculature develops during early brain development. Hypoxia–ischemia (HI) and
hypoxia (H) predispose to brain injury in neonates. Inter-alpha inhibitor proteins (IAIPs) …

Perinatal brain injury is a major cause of morbidity and long-standing disability in newborns.
Hypothermia is the only therapy approved to attenuate brain injury in the newborn. However …