Exosomes are a new means of intercellular information exchange that have aroused great
research interest. Long neglected in research, exosomes were deemed nonfunctional …

Rab proteins are the major regulators of vesicular trafficking in eukaryotic cells. Their activity
can be tightly controlled within cells: Regulated by guanine nucleotide exchange factors …

Following phagocytosis, the nascent phagosome undergoes maturation to become a
phagolysosome with an acidic, hydrolytic, and often oxidative lumen that can efficiently kill …

Eukaryotic cells have systems of internal organelles to synthesize lipids and membrane
proteins, to release secreted proteins, to take up nutrients and to degrade membrane-bound …

Rab GTPases are highly conserved components of vesicle trafficking pathways that help to
ensure the fusion of a vesicle with a specific target organelle membrane. Specific regulatory …

We have identified Rab10 as an ER-specific Rab GTPase that regulates ER structure and
dynamics. We show that Rab10 localizes to the ER and to dynamic ER-associated structures …

Rab molecular switches are key players in defining membrane identity and regulating
intracellular trafficking events in eukaryotic cells. In spite of their global structural similarity …

Eukaryotic cells critically depend on the correct regulation of intracellular vesicular trafficking
to transport biological material. The Rab subfamily of small guanosine triphosphatases …

PtdIns (3, 5) P 2 is one of the seven regulatory PPIn (polyphosphoinositides) that are
ubiquitous in eukaryotes. It controls membrane trafficking at multiple points in the …

Leucine-rich repeat kinase 2 (LRRK2) mutations have been implicated in autosomal
dominant parkinsonism, consistent with typical levodopa-responsive Parkinson's disease …