Abstract Safety tested Modified Vaccinia virus Ankara (MVA) is licensed as third-generation
vaccine against smallpox and serves as a potent vector system for development of new …

Malaria is a mosquito-borne disease caused by parasites of the obligate intracellular
Apicomplexa phylum the most deadly of which, Plasmodium falciparum, prevails in Africa …

Epidemiological observations in malaria endemic areas have long suggested a deficiency in
the generation and maintenance of B cell memory to Plasmodium falciparum (Pf) in …

Recent developments in the use of viruses as vaccine vectors have been facilitated by a
better understanding of viral biology. Advances occur as we gain greater insight into the …

After Edward Jenner established human vaccination over 200 years ago, attenuated
poxviruses became key players to contain the deadliest virus of its own family: Variola virus …

Natural killer (NK) cells are potent immune effectors that can be activated via antibody-
mediated Fc receptor engagement. Using multiparameter flow cytometry, we found that NK …

Malaria caused by Plasmodium falciparum remains a major public health threat, especially
among children and pregnant women in Africa. An effective malaria vaccine would be a …

Abstract Development and Phase 3 testing of the most advanced malaria vaccine, RTS,
S/AS01, indicates that malaria vaccine R&D is moving into a new phase. Field trials of …

Background Infectious diseases often demonstrate heterogeneity of transmission among
host populations. This heterogeneity reduces the efficacy of control strategies, but also …

Background. Vaccine development in human Plasmodium falciparum malaria has been
hampered by the exceptionally high levels of CD8+ T cells required for efficacy. Use of …