Citrate synthase is a key mitochondrial enzyme that utilizes acetyl-CoA and oxaloacetate to
form citrate in the mitochondrial membrane, which participates in energy production in the …

The prevalence of obesity and type 2 diabetes has increased substantially in recent years
creating a global health burden. In obesity, skeletal muscle, the main tissue responsible for …

The sharp increase in obesity prevalence worldwide is mainly attributable to changes in
physical activity and eating behavior but the metabolic and clinical impacts of these …

Citrate synthase (CS) is a key mitochondrial enzyme. The aim of this study was to test the
hypothesis that low CS activity impairs the metabolic health of mice fed a high fat diet (HFD) …

A decrease in TCA cycle activity may lead to impaired nutrition metabolism and cellular
energy shortage. Herein, we aimed to characterize the detailed metabolic changes that …

Dyslipidemia triggers many severe pathologies, including atherosclerosis and chronic
inflammation. Several lines of evidence, including our studies, have suggested direct effects …

Mitochondria provide energy for all cellular processes, including reactions associated with
cell cycle progression, DNA damage repair, and cilia formation. Moreover, mitochondria …

Purpose This study aimed to investigate the effects of downhill treadmill running on
mitochondrial structure/function and expression levels of mitophagy-related proteins in rat …

A/J mouse is a typical animal model of age-related deafness. Previous studies have shown
that the mice suffer from progressive hearing loss and degeneration of cochlear cells, and a …

A/J mouse is a model of age-related hearing loss (AHL). Mutation in the citrate synthase (Cs)
gene of the mouse plays an important role in the hearing loss and degeneration of cochlear …