[HTML][HTML] Advances in antibody phage display technology

L Ledsgaard, A Ljungars, C Rimbault, CV Sørensen… - Drug Discovery …, 2022 - Elsevier
Phage display technology can be used for the discovery of antibodies for research,
diagnostic, and therapeutic purposes. In this review, we present and discuss key parameters …

Ligand-targeted theranostic nanomedicines against cancer

VJ Yao, S D'Angelo, KS Butler, C Theron… - Journal of Controlled …, 2016 - Elsevier
Nanomedicines have significant potential for cancer treatment. Although the majority of
nanomedicines currently tested in clinical trials utilize simple, biocompatible liposome …

Peptides as therapeutic agents: challenges and opportunities in the green transition era

G Rossino, E Marchese, G Galli, F Verde, M Finizio… - Molecules, 2023 - mdpi.com
Peptides are at the cutting edge of contemporary research for new potent, selective, and
safe therapeutical agents. Their rise has reshaped the pharmaceutical landscape, providing …

Combinatorial peptide libraries: mining for cell-binding peptides

BP Gray, KC Brown - Chemical reviews, 2014 - ACS Publications
The surface of a cell represents a collection of macromolecules, which provides the cell with
a unique cellular landscape specific to the type and state of the cell. Ligands that …

In vivo Phage Display: A promising selection strategy for the improvement of antibody targeting and drug delivery properties

AS André, I Moutinho, JNR Dias… - Frontiers in …, 2022 - frontiersin.org
The discovery of hybridoma technology, described by Kohler and Milstein in 1975, and the
resulting ability to generate monoclonal antibodies (mAbs) initiated a new era in antibody …

Prohibitin ligands in cell death and survival: mode of action and therapeutic potential

F Thuaud, N Ribeiro, CG Nebigil, L Désaubry - Chemistry & biology, 2013 - cell.com
Prohibitins (PHBs) are scaffold proteins that modulate many signaling pathways controlling
cell survival, metabolism, and inflammation. Several drugs that target PHBs have been …

Screening of specific binding peptides using phage-display techniques and their biosensing applications

P Xu, S Ghosh, AR Gul, JR Bhamore, JP Park… - TrAC Trends in …, 2021 - Elsevier
Biosensors have been explored for their excellent potential in the field of biological detection
and their application in biomedical diagnosis and have become a rapidly emerging subject …

Design and proof of concept for targeted phage-based COVID-19 vaccination strategies with a streamlined cold-free supply chain

DI Staquicini, FHF Tang, C Markosian… - Proceedings of the …, 2021 - National Acad Sciences
Development of effective vaccines against coronavirus disease 2019 (COVID-19) is a global
imperative. Rapid immunization of the entire human population against a widespread …

Non-invasive early detection of acute transplant rejection via nanosensors of granzyme B activity

QD Mac, DV Mathews, JA Kahla, CM Stoffers… - Nature biomedical …, 2019 - nature.com
The early detection of the onset of transplant rejection is critical for the long-term survival of
patients. The diagnostic gold standard for detecting transplant rejection involves a core …

The role of phage display in therapeutic antibody discovery

CEZ Chan, APC Lim, PA MacAry… - International …, 2014 - academic.oup.com
Phage display involves the expression of selected proteins on the surface of filamentous
phage through fusion with phage coat protein, with the genetic sequence packaged within …