Neurodegeneration in multiple sclerosis involves multiple pathogenic mechanisms
MC Levin, JN Douglas, L Meyers, S Lee… - Degenerative …, 2014 - Taylor & Francis
Multiple sclerosis (MS) is a complex autoimmune disease that impairs the central nervous
system (CNS). The neurological disability and clinical course of the disease is highly …
system (CNS). The neurological disability and clinical course of the disease is highly …
[图书][B] Folate in health and disease
LB Bailey - 2009 - taylorfrancis.com
During the fifteen years since the bestselling first edition of Folate in Health and Disease
was published, there have been thousands of new research studies related to folate and its …
was published, there have been thousands of new research studies related to folate and its …
A systematic review and meta-analysis of controlled trials on the effects of statin and fibrate therapies on plasma homocysteine levels
Background: Plasma homocysteine is an independent non-traditional risk factor for
atherosclerotic cardiovascular disease. The impact of statin therapy on plasma …
atherosclerotic cardiovascular disease. The impact of statin therapy on plasma …
Atorvastatin attenuates bleomycin-induced pulmonary fibrosis via suppressing iNOS expression and the CTGF (CCN2)/ERK signaling pathway
B Zhu, AQ Ma, L Yang, XM Dang - International Journal of Molecular …, 2013 - mdpi.com
Pulmonary fibrosis is a progressive and fatal lung disorder with high mortality rate. To date,
despite the fact that extensive research trials are ongoing, pulmonary fibrosis continues to …
despite the fact that extensive research trials are ongoing, pulmonary fibrosis continues to …
The human MTHFR rs4846049 polymorphism increases coronary heart disease risk through modifying miRNA binding
C Wu, Y Gong, A Sun, Y Zhang, C Zhang… - Nutrition, Metabolism …, 2013 - Elsevier
BACKGROUND AND AIMS: Abnormal functioning of 5, 10-methylenetetrahydrofolate
reductase (MTHFR) enhances the risk for coronary heart disease (CHD). Here, we tested …
reductase (MTHFR) enhances the risk for coronary heart disease (CHD). Here, we tested …
The impact of supplementation with folic acid on homocysteine concentration and selected lipoprotein parameters in patients with primary hypertension
A Baszczuk, A Thielemann, K Musialik… - Journal of nutritional …, 2017 - jstage.jst.go.jp
The aim of the study was the assessment of the impact of supplementation with folic acid on
the concentration of homocysteine, total cholesterol (TC), HDL-and LDL-cholesterol …
the concentration of homocysteine, total cholesterol (TC), HDL-and LDL-cholesterol …
Low dietary folate and methylenetetrahydrofolate reductase deficiency may lead to pregnancy complications through modulation of A po AI and IFN‐γ in spleen and …
Scope Genetic or nutritional disturbances in folate metabolism lead to
hyperhomocysteinemia and adverse reproductive outcomes. Folate‐dependent …
hyperhomocysteinemia and adverse reproductive outcomes. Folate‐dependent …
Siglec-1 on monocytes is a potential risk marker for monitoring disease severity in coronary artery disease
Y Xiong, Y Zhou, G Rong, W Wu, Y Liang, Z Yang… - Clinical …, 2009 - Elsevier
OBJECTIVES: Siglec-1 has long been considered as an important biomarker of the
activation of monocyte/macrophage and a type I interferon-specific imprint, but its role in …
activation of monocyte/macrophage and a type I interferon-specific imprint, but its role in …
Sulforaphane attenuates homocysteine-induced endoplasmic reticulum stress through Nrf-2-driven enzymes in immortalized human hepatocytes
C He, B Li, W Song, Z Ding, S Wang… - Journal of agricultural …, 2014 - ACS Publications
In the present study, we investigated the potential efficacy of cruciferous vegetable-derived
sulforaphane (SFN) in improving homocysteine (HCY)-stressed cells. After human …
sulforaphane (SFN) in improving homocysteine (HCY)-stressed cells. After human …
Transcriptional profiling to identify biomarkers of disease and drug response
DL Mendrick - Pharmacogenomics, 2011 - Taylor & Francis
The discovery, biological qualification and analytical validation of genomic biomarkers
requires extensive collaborations between individuals with expertise in biology, statistics …
requires extensive collaborations between individuals with expertise in biology, statistics …