[HTML][HTML] Brain default-mode network dysfunction in addiction
R Zhang, ND Volkow - Neuroimage, 2019 - Elsevier
Aberrant patterns of brain functional connectivity in the default mode network (DMN) have
been observed across different classes of substance use disorder (SUD) and are associated …
been observed across different classes of substance use disorder (SUD) and are associated …
[HTML][HTML] The association of sleep and pain: an update and a path forward
Ample evidence suggests that sleep and pain are related. However, many questions remain
about the direction of causality in their association, as well as mechanisms that may account …
about the direction of causality in their association, as well as mechanisms that may account …
Control of sleep and wakefulness
This review summarizes the brain mechanisms controlling sleep and wakefulness.
Wakefulness promoting systems cause low-voltage, fast activity in the …
Wakefulness promoting systems cause low-voltage, fast activity in the …
Neurocircuitry of addiction
GF Koob, ND Volkow - Neuropsychopharmacology, 2010 - nature.com
Drug addiction is a chronically relapsing disorder that has been characterized by (1)
compulsion to seek and take the drug,(2) loss of control in limiting intake, and (3) emergence …
compulsion to seek and take the drug,(2) loss of control in limiting intake, and (3) emergence …
Neurocognitive consequences of sleep deprivation
Sleep deprivation is associated with considerable social, financial, and health-related costs,
in large measure because it produces impaired cognitive performance due to increasing …
in large measure because it produces impaired cognitive performance due to increasing …
Sleep deprivation amplifies reactivity of brain reward networks, biasing the appraisal of positive emotional experiences
Appropriate interpretation of pleasurable, rewarding experiences favors decisions that
enhance survival. Conversely, dysfunctional affective brain processing can lead to life …
enhance survival. Conversely, dysfunctional affective brain processing can lead to life …
Imaging dopamine's role in drug abuse and addiction
Dopamine is involved in drug reinforcement but its role in addiction is less clear. Here we
describe PET imaging studies that investigate dopamine's involvement in drug abuse in the …
describe PET imaging studies that investigate dopamine's involvement in drug abuse in the …
The comorbidity of insomnia, chronic pain, and depression: dopamine as a putative mechanism
Epidemiological, cross-sectional, and prospective studies suggest that insomnia, chronic
pain, and depression frequently co-occur and are mutually interacting conditions. However …
pain, and depression frequently co-occur and are mutually interacting conditions. However …
Brain stress systems in the amygdala and addiction
GF Koob - Brain research, 2009 - Elsevier
Dysregulation of the brain emotional systems that mediate arousal and stress is a key
component of the pathophysiology of drug addiction. Drug addiction is a chronically …
component of the pathophysiology of drug addiction. Drug addiction is a chronically …
Total sleep deprivation increases pain sensitivity, impairs conditioned pain modulation and facilitates temporal summation of pain in healthy participants
AT Staffe, MW Bech, SLK Clemmensen, HT Nielsen… - PloS one, 2019 - journals.plos.org
Chronic pain patients often suffer from insomnia or impaired sleep which has been
associated with increased pain sensitivity, but a limited amount of studies have investigated …
associated with increased pain sensitivity, but a limited amount of studies have investigated …