Aberrant patterns of brain functional connectivity in the default mode network (DMN) have
been observed across different classes of substance use disorder (SUD) and are associated …

Ample evidence suggests that sleep and pain are related. However, many questions remain
about the direction of causality in their association, as well as mechanisms that may account …

This review summarizes the brain mechanisms controlling sleep and wakefulness.
Wakefulness promoting systems cause low-voltage, fast activity in the …

Drug addiction is a chronically relapsing disorder that has been characterized by (1)
compulsion to seek and take the drug,(2) loss of control in limiting intake, and (3) emergence …

Sleep deprivation is associated with considerable social, financial, and health-related costs,
in large measure because it produces impaired cognitive performance due to increasing …

Appropriate interpretation of pleasurable, rewarding experiences favors decisions that
enhance survival. Conversely, dysfunctional affective brain processing can lead to life …

Dopamine is involved in drug reinforcement but its role in addiction is less clear. Here we
describe PET imaging studies that investigate dopamine's involvement in drug abuse in the …

Epidemiological, cross-sectional, and prospective studies suggest that insomnia, chronic
pain, and depression frequently co-occur and are mutually interacting conditions. However …

Dysregulation of the brain emotional systems that mediate arousal and stress is a key
component of the pathophysiology of drug addiction. Drug addiction is a chronically …

Chronic pain patients often suffer from insomnia or impaired sleep which has been
associated with increased pain sensitivity, but a limited amount of studies have investigated …