Progress in spray-drying of protein pharmaceuticals: Literature analysis of trends in formulation and process attributes
JT Pinto, E Faulhammer, J Dieplinger, M Dekner… - Drying …, 2021 - Taylor & Francis
Spray-drying is an inherently continuous and well-established industrial drying process. It
can accelerate manufacturing of biopharmaceuticals and vaccine products, resulting in both …
can accelerate manufacturing of biopharmaceuticals and vaccine products, resulting in both …
Developments in hydrogen/deuterium exchange mass spectrometry
Chemistry” on HDX MS. 1 That review covered HDX MS applications from January 2012
through June 2014 and described the publications in terms of sector, geography, and topic …
through June 2014 and described the publications in terms of sector, geography, and topic …
Characterization of selected dietary fibers microparticles and application of the optimized formulation as a fat replacer in hazelnut spreads
RS Zamora, A Baldelli, A Pratap-Singh - Food Research International, 2023 - Elsevier
The present work demonstrates the application of the spray drying technique to produce
microparticulates of different dietary fibers with particle sizes< 10 µm. It examines their role …
microparticulates of different dietary fibers with particle sizes< 10 µm. It examines their role …
Wall Materials for Encapsulating Bioactive Compounds via Spray-Drying: A Review
E Díaz-Montes - Polymers, 2023 - mdpi.com
Spray-drying is a continuous encapsulation method that effectively preserves, stabilizes, and
retards the degradation of bioactive compounds by encapsulating them within a wall …
retards the degradation of bioactive compounds by encapsulating them within a wall …
Pharmaceutical protein solids: Drying technology, solid-state characterization and stability
Despite the boom in biologics over the past decade, the intrinsic instability of these large
molecules poses significant challenges to formulation development. Almost half of all …
molecules poses significant challenges to formulation development. Almost half of all …
Understanding the impact of protein–excipient interactions on physical stability of spray-dried protein solids
Mannitol, leucine, and trehalose have been widely used in spray-dried formulations,
especially for inhalation formulations. The individual contribution of these excipients on …
especially for inhalation formulations. The individual contribution of these excipients on …
Effects of drying method and excipient on the structure and physical stability of protein solids: Freeze drying vs. spray freeze drying
This study aims to determine the impacts of drying method and excipient on changes in
protein structure and physical stability of model protein solids. Protein solids containing one …
protein structure and physical stability of model protein solids. Protein solids containing one …
Effect of buffer salts on physical stability of lyophilized and spray-dried protein formulations containing bovine serum albumin and trehalose
This study examined the effect of buffer salts on the physical stability of spray-dried and
lyophilized formulations of a model protein, bovine serum albumin (BSA). BSA formulations …
lyophilized formulations of a model protein, bovine serum albumin (BSA). BSA formulations …
Inhalable microparticle platform based on a novel shell-forming lipid excipient and its feasibility for respirable delivery of biologics
Administration of biologics such as proteins, vaccines, and phages via the respiratory route
is becoming increasingly popular. Inhalable powder formulations for the successful delivery …
is becoming increasingly popular. Inhalable powder formulations for the successful delivery …
Mechanism of insoluble aggregate formation in a reconstituted solution of spray-dried protein powder
Background Spray-drying is considered a promising alternative drying method to
lyophilization (freeze-drying) for therapeutic proteins. Particle counts in reconstituted …
lyophilization (freeze-drying) for therapeutic proteins. Particle counts in reconstituted …