Despite widespread sex differences in prevalence and presentation of numerous illnesses
affecting the human brain, there has been little focus on the effect of endocrine ageing. Most …

Childhood obesity has become a major health concern in recent decades, especially with
regard to metabolic abnormalities that impart a high risk for future cardiovascular disease …

Since the early 1980s, the focus on the importance of puberty to adolescent development
has continued with variability in the methodology selected to measure puberty. To capture …

Sexual maturation in humans is characterized by a unique individual variability. Pubertal
onset is a highly heritable polygenic trait but it is also affected by environmental factors such …

About 50years after Harris's first demonstration of its existence, GnRH has strongly
stimulated the interest and imagination of scientists, resulting in a high number of studies in …

A recent decline in onset of puberty–especially among girls–has been observed, first in the
US in the mid‐1990s and now also in Europe. The development of breast tissue in girls …

This review presents a comprehensive discussion of the clinical condition of delayed
puberty, a common presentation to the pediatric endocrinologist, which may present both …

The current trends of increasing incidences of testis, breast and prostate cancers are poorly
understood, although it is assumed that sex hormones play a role. Disrupted sex hormone …

Many scientific studies have revealed a trend towards an earlier onset of puberty and have
disclosed an increasing number of children that display precocious puberty. As an …

Gonadal steroids organize the developing brain during a perinatal sensitive period and
have enduring consequences for adult behavior. In male rodents testicular androgens are …