In the early 1960s, shortly after the introduction of oral contraceptives, the first case reports
appeared describing venous thrombosis and pulmonary emboli in women using this method …

Estrogen-containing medication, prescribed either for contraception in women of
reproductive age or for prevention of cardiovascular events and osteoporosis as well as for …

Venous thromboembolism is an episodic disease with an annual incidence of 2 to 3/1000
per year that is associated with a high morbidity and mortality. Risk factors for venous …

The use of oral contraceptives (OC) is a well established risk factor for venous thrombosis. It
has been known for many years that almost all haemostatic parameters ie plasma levels of …

Over the last decade we have witnessed an avalanche of newly identified risk factors for
venous thrombosis. This has advanced our knowledge of its etiology, because more …

The role of the fibrinolytic system in the development of deep vein thrombosis (DVT) is
unclear. We determined the plasma fibrinolytic potential of patients enrolled in the Leiden …

Exogenous hormones are used by more than a hundred million women worldwide as oral
contraceptives or for postmenopausal hormone replacement. Oral contraceptives increase …

The incidence of venous thrombosis associated with estrogen treatment in male-to-female
(M→ F) transsexuals is considerably higher with administration of oral ethinyl estradiol (EE) …

Combined oral contraceptives (OC) are known to increase the risk of venous
thromboembolism. The aim of this randomized, cycle-controlled, cross-over study in 28 …

Hundreds of millions of women worldwide use either oral contraceptives or postmenopausal
hormone replacement. The use of oral contraceptives leads to an increased risk of venous …