Lentiviral vectors (LVs) are potent tools for the delivery of genes of interest into mammalian
cells and are now commonly utilised within the growing field of cell and gene therapy for the …

The host range of retroviral vectors including lentiviral vectors can be expanded or altered
by a process known as pseudotyping. Pseudotyped lentiviral vectors consist of vector …

The causative agent of the COVID-19 pandemic, SARS-CoV-2, is steadily mutating during
continuous transmission among humans. Such mutations can occur in the spike (S) protein …

Generating lentiviral vectors pseudotyped with different viral glycoproteins (GPs) may
modulate the physicochemical properties of the vectors, their interaction with the host …

Retargeting of lentiviral vector entry to cell types of interest is a key factor in improving the
safety and efficacy of gene transfer. In this study we show that the retargetable envelope …

The human endogenous retrovirus type W (HERV-W) family includes proviruses with intact
protein-coding regions that appear to be under selection pressure, suggesting that some …

A major limitation of current lentiviral vectors (LVs) is their inability to govern efficient gene
transfer into quiescent cells such as primary T cells, which hampers their application for …

Sequencing studies of diffuse large B cell lymphoma (DLBCL) have identified hundreds of
recurrently altered genes. However, it remains largely unknown whether and how these …

Bone-marrow-derived mesenchymal stem cells (MSCs) have attracted considerable
attention as tools for the systemic delivery of therapeutic proteins in vivo, and the ability to …

Lentiviral vectors have emerged as promising tools for both gene therapy and
immunotherapy purposes. They exhibit several advantages over other viral systems in that …