For many patients with terminal/advanced cardiac failure, heart transplantation is the most
effective, durable treatment option, and offers the best prospects for a high quality of life. The …

Heart transplantation is the only long-lasting lifesaving option for patients with terminal
cardiac failure. The number of available human organs is however far below the actual …

Background Many genetically multi‐modified donor lines for xenotransplantation have a
background of domestic pigs with rapid body and organ growth. The intrinsic growth …

The future clinical application of animal‐to‐human transplantation (xenotransplantation) is of
importance to society as a whole. Favourable preclinical data relevant to cell, tissue and …

Millions suffer from incurable lung diseases, and the donor lung shortage hampers organ
transplants. Generating the whole organ in conjunction with the thymus is a significant …

SCNT (somatic cell nuclear transfer) has complemented the toolbox of ARTs offering yet
another technique to reproduce animals in an unprecedented way. Despite remarkable …

The birth and adult development of “Dolly” the sheep, the first mammal produced by transfer
of a terminally differentiated cell nucleus into an egg, provided unequivocal evidence of …

The 2-month-survival of a terminally ill patient who received a genetically modified pig heart
has demonstrated that cardiac xenotransplantation could provide a therapeutic option for …

Accommodation refers to acquired resistance of organs or tissues to immune or
inflammatory reactions that might otherwise cause severe injury or rejection. As first …

The rapid development of CRISPR-based gene editing has been accompanied by a
polarized governance debate about the status of CRISPR-edited crops as genetically …