Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

BACKGROUND There is a great inter-individual variability of ovarian ageing, and almost
20% of patients consulting for infertility show signs of premature ovarian ageing. This …

The human ovary orchestrates sex hormone production and undergoes monthly structural
changes to release mature oocytes. The outer lining of the ovary (cortex) has a key role in …

This monograph, written by the pioneers of IVF and reproductive medicine, celebrates the
history, achievements, and medical advancements made over the last 40 years in this …

Mitochondrial dysfunction is one of the hallmarks of aging. Consistently mitochondrial DNA
(mtDNA) copy number and function decline with age in various tissues. There is increasing …

STUDY QUESTION Which add-ons are safe and effective to be used in ART treatment?
SUMMARY ANSWER Forty-two recommendations were formulated on the use of add-ons in …

The hypothalamic-pituitary-ovarian (HPO) axis is a tightly regulated system controlling
female reproduction. HPO axis dysfunction leading to ovulation disorders can be classified …

Advanced maternal age (AMA;> 35 year) is associated with a decline in both ovarian
reserve and oocyte competence. At present, no remedies are available to counteract the …

The development of oocytes and early embryos is dependent on mitochondrial ATP
production. This reliance on mitochondrial activity, together with the exclusively maternal …

Mammals' aging is correlated with the accumulation of somatic heteroplasmic mitochondrial
DNA (mtDNA) mutations. Whether and how aging accumulated mtDNA mutations modulate …