The integration of CRISPR technology with microfluidic-based biosensors has greatly
expanded its applications in medicine and molecular biology. This combination offers …

Immunotherapy plays a key role in cancer treatment, however, responses are limited to a
small number of patients. The biological basis for the success of immunotherapy is the …

Despite much progress, image processing remains a significant bottleneck for high-
throughput analysis of microscopy data. One popular platform for single-cell time-lapse …

Chronic tuberculosis (TB) disease, which requires months-long chemotherapy with multiple
antibiotics, is defined by diverse pathological manifestations and bacterial phenotypes …

Microfluidic platforms enable long-term quantification of stochastic behaviors of individual
bacterial cells under precisely controlled growth conditions. Yet, quantitative comparisons of …

Recently, there has been an increasing need for tools to simulate cell size regulation due to
important applications in cell proliferation and gene expression. However, implementing the …

Bacteria, as the predominant species in mammalian microbiomes, play important roles in the
regulation of host health and disease. Bacterial analysis down to the single-cell level is …

Aging has profound effects on the body, most notably an increase in the prevalence of
several diseases. An important aging hallmark is the presence of senescent cells that no …

Automated microscopy techniques combined with high-throughput microfluidic cultivation
systems provide unique insights into living microorganisms, enabling hundreds of …

For several decades, aging in Saccharomyces cerevisiae has been studied in hopes of
understanding its causes and identifying conserved pathways that also drive aging in …