Chronic (neuro) inflammation plays an important role in many age-related central nervous
system (CNS) diseases, including Alzheimer's disease, Parkinson's disease and vascular …

Recent studies have shown that overweight and obesity play an important role in the
development of osteoarthritis (OA). However, joint overload is not the only risk factor in this …

Reactive astrocytes (RA) secrete lipocalin-2 (LCN2) glycoprotein that regulates diverse
cellular processes including cell death/survival, inflammation, iron delivery and cell …

Astrocytes, which are homeostatic cells of the central nervous system (CNS), display
remarkable heterogeneity in their morphology and function. Besides their physical and …

Alzheimer's disease (AD) is the most common cause of dementia, affecting 35 million people
worldwide. One pathological feature of progressing AD is the loss of synapses. This is the …

Abstract Lipocalin-2 (LCN2) is an acute-phase protein that, by binding to iron-loaded
siderophores, acts as a potent bacteriostatic agent in the iron-depletion strategy of the …

Alzheimer's disease (AD) is the most common form of dementia, whose prevalence is
growing along with the increased life expectancy. Although the accumulation and deposition …

Abstract Lipocalin-2 (LCN2) is an acute phase protein with multiple functions that has
garnered a great deal of interest over the last decade. However, its precise role in the …

Dementia, osteoporosis, and fragility fractures are chronic diseases, often co-existing in
older adults. These conditions pose severe morbidity, long-term disability, and mortality, with …

Abstract Lipocalin-2 (LCN2) is a member of the secreted lipocalin protein family. LCN2 is
also a representative gliocalin that is primarily released by glial cells, as well as acts upon …