Transport of newly synthesized proteins from the endoplasmic reticulum (ER) to the Golgi
complex is highly selective. As a general rule, such transport is limited to soluble and …

Cargo molecules have to be included in carrier vesicles of different forms and sizes to be
transported between organelles. During this process, a limited set of proteins, including the …

Deregulation of Akt/protein kinase B (PKB) is implicated in the pathogenesis of cancer and
diabetes. Akt/PKB activation requires the phosphorylation of Thr308 in the activation loop by …

▪ Abstract Green fluorescent protein chimerae acting as reporters for protein localization and
trafficking within the secretory membrane system of living cells have been used in a wide …

Transport of membranes and proteins in eukaryotic cells is mediated by vesicular carriers.
Here we review the biogenesis and functions of COPI vesicles, carriers that operate in the …

Estimates based on proteomic analyses indicate that a third of translated proteins in
eukaryotic genomes enter the secretory pathway. After folding and assembly of nascent …

The mechanism, in molecular terms of protein quality control, specifically of how the cell
recognizes and discriminates misfolded proteins, remains a challenge. In the secretory …

We visualized a fluorescent-protein (FP) fusion to Rab6, a Golgi-associated GTPase, in
conjunction with fluorescent secretory pathway markers. FP-Rab6 defined highly dynamic …

Proteinase-activated receptors (PARs) are a subfamily of G protein-coupled receptors
(GPCRs) with four members, PAR 1, PAR 2, PAR 3 and PAR 4, playing critical functions in …

The coat protein complex I (COPI) allows the precise sorting of lipids and proteins between
Golgi cisternae and retrieval from the Golgi to the ER. This essential role maintains the …