Histone deacetylases comprise a family of 18 genes, which are grouped into classes I–IV
based on their homology to their respective yeast orthologues. Classes I, II, and IV consist of …

Histone deacetylase (HDAC) 6 is the best‐characterized class II b deacetylase that
regulates many important biological processes via the formation of complexes with its …

Zinc binding groups (ZBGs) play a crucial role in targeting histone deacetylase inhibitors
(HDACIs) to the active site of histone deacetylases (HDACs), thus determining the potency …

Histone deacetylase inhibitors are a large group of diverse molecules intrinsically able to
inhibit cell proliferation in various cancer cell lines. Their apoptotic effects have been linked …

This review classifies drug‐design strategies successfully implemented in the development
of histone deacetylase (HDAC) inhibitors, which have many applications including cancer …

Histone deacetylase (HDAC) proteins are transcription regulators linked to cancer. As a
result, multiple small molecule HDAC inhibitors are in various phases of clinical trials as anti …

Abstract Foxp3+ T-regulatory cells (Tregs) are key to immune homeostasis such that their
diminished numbers or function can cause autoimmunity and allograft rejection. Foxp3+ …

This Perspective provides an in depth look at the numerous disease states in which histone
deacetylase 6 (HDAC6) has been implicated. The physiological pathways, protein–protein …

Accumulation of misfolded proteins in proteinaceous inclusions is a prominent pathological
feature common to many agerelated neurodegenerative diseases, including Parkinson's …

To find HDAC8-selective inhibitors, we designed a library of HDAC inhibitor candidates,
each containing a zinc-binding group that coordinates with the active-site zinc ion, linked via …