DNA damage—how and why we age?
Aging is a complex process that results in loss of the ability to reattain homeostasis following
stress, leading, thereby, to increased risk of morbidity and mortality. Many factors contribute …
stress, leading, thereby, to increased risk of morbidity and mortality. Many factors contribute …
[HTML][HTML] Promoting health and longevity through diet: from model organisms to humans
L Fontana, L Partridge - Cell, 2015 - cell.com
Reduced food intake, avoiding malnutrition, can ameliorate aging and aging-associated
diseases in invertebrate model organisms, rodents, primates, and humans. Recent findings …
diseases in invertebrate model organisms, rodents, primates, and humans. Recent findings …
Branched chain amino acids, aging and age-related health
Branched chain amino acids (BCAA: leucine, valine, isoleucine) have key physiological
roles in the regulation of protein synthesis, metabolism, food intake and aging. Many studies …
roles in the regulation of protein synthesis, metabolism, food intake and aging. Many studies …
[HTML][HTML] Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population
Mice and humans with growth hormone receptor/IGF-1 deficiencies display major reductions
in age-related diseases. Because protein restriction reduces GHR-IGF-1 activity, we …
in age-related diseases. Because protein restriction reduces GHR-IGF-1 activity, we …
Ketone bodies as signaling metabolites
JC Newman, E Verdin - Trends in Endocrinology & Metabolism, 2014 - cell.com
Traditionally, the ketone body β-hydroxybutyrate (βOHB) has been looked upon as a carrier
of energy from liver to peripheral tissues during fasting or exercise. However, βOHB also …
of energy from liver to peripheral tissues during fasting or exercise. However, βOHB also …
Caloric restriction
JR Speakman, SE Mitchell - Molecular aspects of medicine, 2011 - Elsevier
Restricting the intake of calories has been practiced as a method for increasing both the
length and quality of life for over 500years. Experimental work confirming the success of this …
length and quality of life for over 500years. Experimental work confirming the success of this …
The impact of religious fasting on human health
JF Trepanowski, RJ Bloomer - Nutrition journal, 2010 - Springer
The past two decades have seen a rise in the number of investigations examining the health-
related effects of religiously motivated fasts. Islamic Ramadan is a 28-30 day fast in which …
related effects of religiously motivated fasts. Islamic Ramadan is a 28-30 day fast in which …
Methionine restriction and cancer biology
D Wanders, K Hobson, X Ji - Nutrients, 2020 - mdpi.com
The essential amino acid, methionine, is important for cancer cell growth and metabolism. A
growing body of evidence indicates that methionine restriction inhibits cancer cell growth …
growing body of evidence indicates that methionine restriction inhibits cancer cell growth …
Updating the mitochondrial free radical theory of aging: an integrated view, key aspects, and confounding concepts
G Barja - Antioxidants & redox signaling, 2013 - liebertpub.com
An updated version of the mitochondrial free radical theory of aging (MFRTA) and longevity
is reviewed. Key aspects of the theory are emphasized. Another main focus concerns …
is reviewed. Key aspects of the theory are emphasized. Another main focus concerns …
Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism
Background Dietary restriction (DR), a reduction in food intake without malnutrition,
increases most aspects of health during aging and extends lifespan in diverse species …
increases most aspects of health during aging and extends lifespan in diverse species …