Background The ganglionated plexuses (GPs) of the intrinsic cardiac autonomic system may
play a role in atrial fibrillation (AF). Objective We hypothesized that ablating the ectopy …

Evidence has accumulated over the last century of the importance of a critical electrical
mass in sustaining atrial fibrillation (AF). AF ablation certainly reduces electrically …

Abstract Background Ganglionated plexuses (GPs) are implicated in atrial fibrillation (AF).
Endocardial high‐frequency stimulation (HFS) delivered within the local atrial refractory …

For more than 2 decades, radiofrequency (RF) and cryoenergy have dominated the field of
electrophysiology as the primary modes of energy for atrial fibrillation (AF) ablation. Yet …

Background Recent study has shown that the transient receptor potential vanilloid 2
(TRPV2) channel was exclusively upregulated in patients with atrial fibrillation (AF), and that …

Aims The response to high frequency stimulation (HFS) is used to locate putative sites of
ganglionated plexuses (GPs), which are implicated in triggering atrial fibrillation (AF). To …

Background Ablation of autonomic ectopy-triggering ganglionated plexuses (ET-GP) has
been used to treat paroxysmal atrial fibrillation (AF). It is not known if ET-GP localisation is …

The optimal ablation strategy for persistent atrial fibrillation (PsAF) remains to be defined.
We sought to compare very long-term outcomes between linear ablation and electrogram …

Atrial fibrillation (AF) is a major healthcare burden worldwide. For AF that is resistant to
pharmacological intervention, the standard invasive treatment is a pulmonary vein isolation …

A universal description of mechanisms of AF activation remains elusive. This thesis seeks to
apply emerging techniques of global non-contact mapping to further understand …