Cartilage is a tension-and load-bearing tissue and has a limited capacity for intrinsic self-
healing. While microfracture and arthroplasty are the conventional methods for cartilage …

Cartilage injury originating from trauma or osteoarthritis is a common joint disease that can
bring about an increasing social and economic burden in modern society. On account of its …

Successful osteochondral defect repair requires regenerating the subchondral bone whilst
simultaneously promoting the development of an overlying layer of articular cartilage that is …

Modular biofabrication strategies using microtissues or organoids as biological building
blocks have great potential for engineering replacement tissues and organs at scale. Here …

Engineering constructs that mimic the complex structure, composition and biomechanics of
the articular cartilage represents a promising route to joint regeneration. Such tissue …

Tissue engineered constructs have the potential to respond to the unmet medical need of
treating deep osteochondral defects. However, current tissue engineering strategies …

Damaged or diseased bone can be treated using autografts or a range of different bone
grafting biomaterials, however limitations with such approaches has motivated increased …

Articular cartilage lesion such as osteoarthritis (OA) is becoming a serious threat to global
human health. In recent years, as a new paradigm in cartilage tissue engineering and …

Over the decades, the management of osteochondral lesions remains a significant yet
unmet medical challenge without curative solutions to date. Owing to the complex nature of …

Stem cell-based therapy is a promising treatment for cartilage defects due to the
pluripotency, abundant sources and low immunogenicity of stem cells. Hydrogels are a …