The discovery of regulated cell death presents tantalizing possibilities for gaining control
over the life–death decisions made by cells in disease. Although apoptosis has been the …

Cell death research was revitalized by the understanding that necrosis can occur in a highly
regulated and genetically controlled manner. Although RIPK1 (receptor-interacting protein …

The mitochondrial permeability transition (PT)–an abrupt increase permeability of the inner
membrane to solutes–is a causative event in ischemia–reperfusion injury of the heart, and …

AKI is pathologically characterized by sublethal and lethal damage of renal tubules. Under
these conditions, renal tubular cell death may occur by regulated necrosis (RN) or …

The permeability transition (PT) denotes an increase of the mitochondrial inner membrane
permeability to solutes with molecular masses up to about 1500 Da. It is presumed to be …

The mitochondrial permeability transition pore was originally described in the 1970's as a
Ca 2+ activated pore and has since been attributed to the pathogenesis of many diseases …

1112 ELROD JW et al. red-sensitive mechanism (now known to be the mitochondrial
calcium uniporter (MCU), the genetic identity of which was recently discovered14–16) and …

Necroptosis is a form of programmed necrosis mediated by signaling complexes with
receptor-interacting protein 1 (RIP1) and RIP3 kinases as the main mediators. However, the …

Mitochondria serve as a “powerhouse” which provides near 90% of ATP necessary for cell
life. However, recent studies provide strong evidence that mitochondria also play a central …

In contrast to apoptosis and autophagy, necrotic cell death was considered to be a random,
passive cell death without definable mediators. However, this dogma has been challenged …