Abstract p53 is a key tumor suppressor, and loss of p53 function is frequently a prerequisite
for cancer development. The p53 gene is the most frequently mutated gene in human …

The p53 protein is mutated in about 50% of human cancers. Aside from losing the tumor-
suppressive functions of the wild-type form, mutant p53 proteins often acquire inherent …

Abstract The Cancer Programme of the 100,000 Genomes Project was an initiative to
provide whole-genome sequencing (WGS) for patients with cancer, evaluating opportunities …

The key role of p53 as a tumor suppressor became clear when it was realized that this gene
is mutated in 50% of human sporadic cancers, and germline mutations expose carriers to …

The tumor suppressor p53 maintains an equilibrium between self-renewal and
differentiation to sustain a limited repertoire of stem cells for proper development and …

Missense mutations in TP53 comprise> 75% of all p53 alterations in cancer, resulting in
highly stabilized mutant p53 proteins that not only lose their tumor-suppressor activity, but …

Cells are constantly exposed to endogenous and exogenous factors that threaten the
integrity of their DNA. The maintenance of genome stability is of paramount importance in …

Emerging notion in carcinogenesis ascribes tumor initiation and aggressiveness to cancer
stem cells (CSCs). Specifically, colorectal cancer (CRC) development was shown to be …

Encoded by the mutated variants of the TP53 tumor suppressor gene, mutant p53 proteins
are getting an increased experimental support as active oncoproteins promoting tumor …

It is well accepted that expression of mutant p53 involves the gain of oncogenic-specific
activities accentuating the malignant phenotype. Depending on the specific cancer type …