Early life adversity shapes neural circuit function during sensitive postnatal developmental periods

L Malave, MT van Dijk, C Anacker - Translational psychiatry, 2022 - nature.com
Early life adversity (ELA) is a major risk factor for mental illness, but the neurobiological
mechanisms by which ELA increases the risk for future psychopathology are still poorly …

Adult hippocampal neurogenesis and cognitive flexibility—linking memory and mood

C Anacker, R Hen - Nature Reviews Neuroscience, 2017 - nature.com
Adult hippocampal neurogenesis has been implicated in cognitive processes, such as
pattern separation, and in the behavioural effects of stress and antidepressants. Young adult …

Polycystic ovary syndrome (PCOS), an inflammatory, systemic, lifestyle endocrinopathy

S Patel - The Journal of steroid biochemistry and molecular …, 2018 - Elsevier
Polycystic ovary syndrome (PCOS) is an endocrine disorder, afflicting females of
reproductive age. This syndrome leads to infertility, insulin resistance, obesity, and …

High cortisol and the risk of dementia and Alzheimer's disease: a review of the literature

S Ouanes, J Popp - Frontiers in aging neuroscience, 2019 - frontiersin.org
Introduction: Cortisol effects on the brain are exerted through two distinct receptors, inducing
complex and even opposite effects on the cerebral structures implicated in the various …

Peripheral markers of depression

A Nobis, D Zalewski, N Waszkiewicz - Journal of clinical medicine, 2020 - mdpi.com
Major Depressive Disorder (MDD) is a leading cause of disability worldwide, creating a high
medical and socioeconomic burden. There is a growing interest in the biological …

The role of the hypothalamus–pituitary–adrenal (HPA) axis in test-induced anxiety: assessments, physiological responses, and molecular details

JA Hinds, ER Sanchez - Stresses, 2022 - mdpi.com
Test anxiety may be a contributing factor to low-performing examination scores among
students. There can be numerous physiological responses in the body that lead to test …

Cortisol dysregulation: the bidirectional link between stress, depression, and type 2 diabetes mellitus

JJ Joseph, SH Golden - Annals of the New York Academy of …, 2017 - Wiley Online Library
Controversy exists over the role of stress and depression in the pathophysiology of type 2
diabetes mellitus. Depression has been shown to increase the risk for progressive insulin …

The future of rodent models in depression research

A Gururajan, A Reif, JF Cryan, DA Slattery - Nature Reviews …, 2019 - nature.com
Currently, over 300 million people worldwide have depression, and the socioeconomic
burden of this debilitating disorder is anticipated to increase markedly over the coming …

Stress and obesity: are there more susceptible individuals?

ES Van der Valk, M Savas, EFC van Rossum - Current obesity reports, 2018 - Springer
Abstract Purpose of Review Stress has long been suspected to be interrelated to
(abdominal) obesity. However, interindividual differences in this complex relationship exist …

From stress to inflammation and major depressive disorder: a social signal transduction theory of depression.

GM Slavich, MR Irwin - Psychological bulletin, 2014 - psycnet.apa.org
Major life stressors, especially those involving interpersonal stress and social rejection, are
among the strongest proximal risk factors for depression. In this review, we propose a …