Mitochondria are vital organelles with distinct morphological features and functional
properties. The dynamic network of mitochondria undergoes structural and functional …

Synaptic activity imposes large energy demands that are met by local adenosine
triphosphate (ATP) synthesis through glycolysis and mitochondrial oxidative …

Mitochondria have a number of essential roles in neuronal function. Their complex mobility
patterns within neurons are characterized by frequent changes in direction. Mobile …

Bipolar disorder (BPD) and schizophrenia (SZ) are severe psychiatric illnesses with a
combined prevalence of 4%. A disturbance of energy metabolism is frequently observed in …

Mitochondria are cellular power plants that supply ATP to power various biological activities
essential for neuronal growth, survival, and function. Due to unique morphological features …

Iron deficiency (ID) is the most common nutrient deficiency, affecting 2 billion people and
30% of pregnant women and their offspring. Early life ID affects at least 3 major …

Mitochondria in neurons, in addition to their primary role in bioenergetics, also contribute to
specialized functions, including regulation of synaptic transmission, Ca2+ homeostasis …

Mitochondria play an essential role in ATP generation, calcium buffering and apoptotic
signalling. In neurons, the transport of mitochondria to specific locations where they are …

Background Tubulin is a major substrate of the cytoplasmic class II histone deacetylase
HDAC6. Inhibition of HDAC6 results in higher levels of acetylated tubulin and enhanced …

Background Bipolar disorder phenomenologically is a biphasic disorder of energy
availability; increased in mania and decreased in depression. In consort, there is …