A comprehensive survey of regulatory network inference methods using single cell RNA sequencing data
Gene regulatory network is a complicated set of interactions between genetic materials,
which dictates how cells develop in living organisms and react to their surrounding …
which dictates how cells develop in living organisms and react to their surrounding …
Single-cell transcriptional diversity is a hallmark of developmental potential
GS Gulati, SS Sikandar, DJ Wesche, A Manjunath… - Science, 2020 - science.org
Single-cell RNA sequencing (scRNA-seq) is a powerful approach for reconstructing cellular
differentiation trajectories. However, inferring both the state and direction of differentiation is …
differentiation trajectories. However, inferring both the state and direction of differentiation is …
An old weapon with a new function: PIWI-interacting RNAs in neurodegenerative diseases
PIWI-interacting RNAs (piRNAs) are small non-coding transcripts that are highly conserved
across species and regulate gene expression through pre-and post-transcriptional …
across species and regulate gene expression through pre-and post-transcriptional …
Neuron-specific signatures in the chromosomal connectome associated with schizophrenia risk
INTRODUCTION Chromosomal conformations, topologically associated chromatin domains
(TADs) assembling in nested fashion across hundreds of kilobases, and other “three …
(TADs) assembling in nested fashion across hundreds of kilobases, and other “three …
Single‐cell analysis reveals dynamic changes of neural cells in developing human spinal cord
Q Zhang, X Wu, Y Fan, P Jiang, Y Zhao, Y Yang… - EMBO …, 2021 - embopress.org
During central nervous system development, neurogenesis and gliogenesis occur in an
orderly manner to create precise neural circuitry. However, no systematic dataset of neural …
orderly manner to create precise neural circuitry. However, no systematic dataset of neural …
Defining the teratoma as a model for multi-lineage human development
We propose that the teratoma, a recognized standard for validating pluripotency in stem
cells, could be a promising platform for studying human developmental processes …
cells, could be a promising platform for studying human developmental processes …
Robust integration of multiple single-cell RNA sequencing datasets using a single reference space
In many biological applications of single-cell RNA sequencing (scRNA-seq), an integrated
analysis of data from multiple batches or studies is necessary. Current methods typically …
analysis of data from multiple batches or studies is necessary. Current methods typically …
Overview of PAX gene family: analysis of human tissue-specific variant expression and involvement in human disease
Paired-box (PAX) genes encode a family of highly conserved transcription factors found in
vertebrates and invertebrates. PAX proteins are defined by the presence of a paired domain …
vertebrates and invertebrates. PAX proteins are defined by the presence of a paired domain …
Single-cell transcriptomics identifies master regulators of neurodegeneration in SOD1 ALS iPSC-derived motor neurons
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative condition characterized by
the loss of motor neurons. We utilized single-cell transcriptomics to uncover dysfunctional …
the loss of motor neurons. We utilized single-cell transcriptomics to uncover dysfunctional …
Quantifying Waddington's epigenetic landscape: a comparison of single-cell potency measures
Motivation: Estimating differentiation potency of single cells is a task of great biological and
clinical significance, as it may allow identification of normal and cancer stem cell …
clinical significance, as it may allow identification of normal and cancer stem cell …