The SR protein family comprises a number of phylogenetically conserved and structurally
related proteins with a characteristic domain rich in arginine and serine residues, known as …

Members of the serine/arginine-rich (SR) protein family have multiple functions in the pre-
mRNA splicing reaction. In addition to being required for the removal of constitutively spliced …

Haplodiploid organisms comprise about 20% of animals. Males develop from unfertilized
eggs while females are derived from fertilized eggs. The underlying mechanisms of sex …

Sexual orientation and courtship behavior in Drosophila are regulated by fruitless (fru), the
first gene in a branch of the sex-determination hierarchy functioning specifically in the …

▪ Abstract Alternative splicing of pre-mRNAs is a powerful and versatile regulatory
mechanism that can effect quantitative control of gene expression and functional …

Spinal muscular atrophy (SMA), a common motor neuron disease in humans, results from
loss of functional survival motor neuron (SMN1) alleles. A nearly identical copy of the gene …

Nature has evolved an astonishing variety of genetic and epigenetic sex-determining
systems which all achieve the same result, the generation of two sexes. Genetic and …

REVIEW There is substantial cytogenetic data indicating that the process of sex
determination can evolve relatively rapidly. However, recent molecular studies on the …

The molecular mechanisms that control sexual dimorphism are very different in distantly
related animals. Did sex determination arise several times with different regulatory …

Capping, splicing, and cleavage/polyadenylation of pre-mRNAs are interdependent events
that are all stimulated in vivo by the carboxy-terminal domain (CTD) of RNA Pol II. We show …