Solid dosage forms of biopharmaceuticals such as therapeutic proteins could provide
enhanced bioavailability, improved storage stability, as well as expanded alternatives to …

The quest to eliminate the needle from insulin delivery and to replace it with non-or less-
invasive alternative routes has driven rigorous pharmaceutical research to replace the …

Several abnormalities of the respiratory function have been reported in patients with type 1
and type 2 diabetes. These abnormalities concern lung volume, pulmonary diffusing …

Diabetes mellitus is a chronic, progressive, incompletely understood metabolic disorder
whose prevalence has been increasing steadily worldwide. Even though little attention has …

In type 1 diabetes (T1D), there is an intense inflammatory response that destroys the β cells
in the pancreatic islets of Langerhans, the site where insulin is produced and released. A …

Due to recent developments in biochemical engineering and in the understanding of the
physiopathology of many diseases, therapeutic biologics are expected to become of …

Patients with diabetes are over-represented among the total cases reported with “idiopathic”
pulmonary fibrosis (IPF). This raises the question, whether this is an association only or …

OBJECTIVE To compare the efficacy and safety of Technosphere insulin (TI) and insulin
aspart in patients with type 1 diabetes. RESEARCH DESIGN AND METHODS This open …

This article is a chapter in the ISPAD Clinical Practice Consensus Guidelines 2009
Compendium. The complete set of guidelines can be found at www. ispad. org. The …

The discovery of insulin was presented to the international medical community on May 3,
1922. Since then, insulin has become one of the most effective pharmacological agents …