Over the past decade there has been increased awareness of the potential role of
alternative splicing in the etiology of cancer. In particular, advances in RNA-Sequencing …

Alternative splicing (AS) serves as a pivotal mechanism in transcriptional regulation,
engendering transcript diversity, and modifications in protein structure and functionality …

Immunotherapy has emerged as a crucial strategy to combat cancer by “reprogramming” a
patient's own immune system. Although immunotherapy is typically reserved for patients with …

The ubiquity of RNA-seq has led to many methods that use RNA-seq data to analyze
variations in RNA splicing. However, available methods are not well suited for handling …

Splicing factor mutations are common in myelodysplastic syndrome (MDS) and acute
myeloid leukemia (AML), but how they alter cellular functions is unclear. We show that the …

This research sought to elucidate the mechanism underlying the self-renewal capacity of
leukemic stem cells (LSCs) to offer new insights into the treatment of acute myeloid leukemia …

Systematic studies of germ line genetic predisposition to myeloid neoplasms in adult
patients are still limited. In this work, we performed germ line and somatic targeted …

Identification of cancer sub-types is a pivotal step for developing personalized treatment.
Specifically, sub-typing based on changes in RNA splicing has been motivated by several …

In myeloid malignancies including acute myeloid leukemia (AML) and myelodysplastic
syndromes (MDS), patient selection and therapeutic strategies are increasingly based on …

Mapping transcriptomic variations using either short-or long-read RNA sequencing is a
staple of genomic research. Long reads are able to capture entire isoforms and overcome …