[HTML][HTML] Insights into adenovirus host cell interactions from structural studies

GR Nemerow, L Pache, V Reddy, PL Stewart - Virology, 2009 - Elsevier
Human adenoviruses cause a significant number of acute respiratory, enteric and ocular
infections, however they have also served as useful model systems for uncovering …

The influence of adenovirus fiber structure and function on vector development for gene therapy

SA Nicklin, E Wu, GR Nemerow, AH Baker - Molecular Therapy, 2005 - cell.com
The collective attributes of adenoviruses (Ads), including ease of accomplishing replication
deficiency, readily achievable high titers, encoding of large expression cassettes, efficiency …

Difference imaging of adenovirus: bridging the resolution gap between X‐ray crystallography and electron microscopy.

PL Stewart, SD Fuller, RM Burnett - The EMBO journal, 1993 - embopress.org
While X‐ray crystallography provides atomic resolution structures of proteins and small
viruses, electron microscopy provides complementary structural information on the …

A triple β-spiral in the adenovirus fibre shaft reveals a new structural motif for a fibrous protein

MJ Van Raaij, A Mitraki, G Lavigne, S Cusack - Nature, 1999 - nature.com
Human adenoviruses are responsible for respiratory, gastro-enteric and ocular infections
and can serve as gene therapy vectors. They form icosahedral particles with 240 copies of …

Image reconstruction reveals the complex molecular organization of adenovirus

PL Stewart, RM Burnett, M Cyrklaff, SD Fuller - Cell, 1991 - cell.com
The three-dimensional structure of adenovirus has been determined by image
reconstruction from cryoelectron micrographs. Comparison with the high resolution X-ray …

The structure of the human adenovirus 2 penton

C Zubieta, G Schoehn, J Chroboczek, S Cusack - Molecular cell, 2005 - cell.com
The adenovirus penton, a noncovalent complex of the pentameric penton base and trimeric
fiber proteins, comprises the vertices of the adenovirus capsid and contains all necessary …

Rabies virus glycoprotein is a trimer

Y Gaudin, RWH Ruigrok, C Tuffereau, M Knossow… - Virology, 1992 - Elsevier
The oligomerization state of the rabies virus envelope glycoprotein (G protein) was
determined using electron microscopy and sedimentation analysis of detergent solubilized …

Crystal structure of the receptor-binding domain of adenovirus type 5 fiberprotein at 1.7 Å resolution

D Xia, LJ Henry, RD Gerard, J Deisenhofer - Structure, 1994 - cell.com
Background: Adenoviral infection begins with the binding of virion to the surface of host
cells. Specific attachment is achieved through interactions between host-cell receptors and …

Characterization of the knob domain of the adenovirus type 5 fiber protein expressed in Escherichia coli

LJ Henry, DI Xia, ME Wilke, J Deisenhofer… - Journal of …, 1994 - Am Soc Microbiol
The adenovirus fiber protein is used for attachment of the virus to a specific receptor on the
cell surface. Structurally, the protein consists of a long, thin shaft that protrudes from the …

[HTML][HTML] Crystal structure of reovirus attachment protein σ1 reveals evolutionary relationship to adenovirus fiber

JD Chappell, AE Prota, TS Dermody, T Stehle - The EMBO journal, 2002 - embopress.org
Reovirus attaches to cellular receptors with the σ1 protein, a fiber‐like molecule protruding
from the 12 vertices of the icosahedral virion. The crystal structure of a receptor‐binding …