Freund, Tamás F., István Katona, and Daniele Piomelli. Role of Endogenous Cannabinoids
in Synaptic Signaling. Physiol Rev 83: 1017–1066, 2003; 10.1152/physrev. 00004.2003 …

Much evidence indicates that, after learning, memories are created by alterations in
glutamate-dependent excitatory synaptic transmission. These modifications are then actively …

Dendritic calcium signaling is central to neural plasticity mechanisms that allow animals to
adapt to the environment. Intracellular calcium release (ICR) from the endoplasmic reticulum …

The hippocampus is one of a group of remarkable structures embedded within the brain's
medial temporal lobe. Long known to be important for memory, it has been a prime focus of …

Most synaptic inputs are made onto the dendritic tree. Recent work has shown that dendrites
play an active role in transforming synaptic input into neuronal output and in defining the …

The endoplasmic reticulum (ER) is the largest single intracellular organelle, which is present
in all types of nerve cells. The ER is an interconnected, internally continuous system of …

Transient rises in the cytoplasmic concentration of calcium ions serve as second messenger
signals that control many neuronal functions. Selective triggering of these functions is …

The possibility that mechanisms of synaptic modulation differ between males and females
has far-reaching implications for understanding brain disorders that vary between the sexes …

All cells use changes in intracellular calcium concentration ([Ca2+] i) to regulate cell
signalling events. In neurons, with their elaborate dendritic and axonal arborizations, there …

Neuronal Ca2+ signaling through inositol triphosphate receptors (IP3R) and ryanodine
receptors (RyRs) must be tightly regulated to maintain cell viability, both acutely and over a …