The Genetic Determinants of Axial Length: From Microphthalmia to High Myopia in Childhood

D Jackson, M Moosajee - Annual Review of Genomics and …, 2023 - annualreviews.org
The axial length of the eye is critical for normal visual function by enabling light to precisely
focus on the retina. The mean axial length of the adult human eye is 23.5 mm, but the …

Myopia prevalence and ocular biometry features in a general Japanese population: the Nagahama Study

S Nakao, M Miyake, Y Hosoda, E Nakano, Y Mori… - Ophthalmology, 2021 - Elsevier
Purpose To describe the distribution of ocular biometry and refraction in Japanese adults.
Design Cross-sectional analysis of a prospective cohort study. Participants A total of 9850 …

A wireless battery-free eye modulation patch for high myopia therapy

T Zhong, H Yi, J Gou, J Li, M Liu, X Gao, S Chen… - Nature …, 2024 - nature.com
The proper axial length of the eye is crucial for achieving emmetropia. In this study, we
present a wireless battery-free eye modulation patch designed to correct high myopia and …

[HTML][HTML] Genome-wide association study of axial length in population-based cohorts in Japan: the tohoku medical megabank organization eye study

N Fuse, M Sakurai, IN Motoike, K Kojima… - Ophthalmology …, 2022 - Elsevier
Purpose To elucidate the differences in ocular biometric parameters by generation and
gender and to identify axial length (AL)-associated genetic variants in Japanese individuals …

ANGPTL7, a therapeutic target for increased intraocular pressure and glaucoma

K Praveen, GC Patel, L Gurski, AH Ayer… - Communications …, 2022 - nature.com
Glaucoma is a leading cause of blindness. Current glaucoma medications work by lowering
intraocular pressure (IOP), a risk factor for glaucoma, but most treatments do not directly …

Vision-related convergent gene losses reveal SERPINE3's unknown role in the eye

H Indrischek, J Hammer, A Machate, N Hecker… - Elife, 2022 - elifesciences.org
Despite decades of research, knowledge about the genes that are important for
development and function of the mammalian eye and are involved in human eye disorders …

Identification of MFRP and the secreted serine proteases PRSS56 and ADAMTS19 as part of a molecular network involved in ocular growth regulation

S Koli, C Labelle-Dumais, Y Zhao, S Paylakhi… - PLoS …, 2021 - journals.plos.org
Precise regulation of ocular size is a critical determinant of normal visual acuity. Although it
is generally accepted that ocular growth relies on a cascade of signaling events transmitted …

Axial length distributions in patients with genetically confirmed inherited retinal diseases

KM Williams, M Georgiou, A Kalitzeos… - … & visual science, 2022 - iovs.arvojournals.org
Purpose: We investigated axial length (AL) distributions in inherited retinal diseases (IRDs),
comparing them with reference cohorts. Methods: AL measurements from IRD natural history …

Complement-mediated inflammation and mitochondrial energy metabolism in the proteomic profile of myopic human corneas

T Huang, Y Wang, Z Wang, Q Long, Y Li, D Chen - Journal of Proteomics, 2023 - Elsevier
Myopia is one of the most common causes of visual impairment worldwide. To identify
proteins related to myopiagenesis, data-independent acquisition proteomic analysis was …

[HTML][HTML] Prevalence and inconformity of refractive errors and ocular biometry of 3573 medical university freshman students for 4 consecutive years

HJ Gao, HM Zhang, WY Dang, L Liu, Y Zhu… - International Journal …, 2022 - ncbi.nlm.nih.gov
AIM To evaluate the prevalence of refractive errors and ocular biometry in 3573 freshman
students at Tianjin Medical University for 4 consecutive years. METHODS In this university …