Immunotherapy in the treatment of metastatic melanoma: current knowledge and future directions
M Ralli, A Botticelli, IC Visconti… - Journal of …, 2020 - Wiley Online Library
Melanoma is one of the most immunologic malignancies based on its higher prevalence in
immune‐compromised patients, the evidence of brisk lymphocytic infiltrates in both primary …
immune‐compromised patients, the evidence of brisk lymphocytic infiltrates in both primary …
Survivin as a biological biomarker for diagnosis and therapy
Y Li, W Lu, J Yang, M Edwards… - Expert opinion on …, 2021 - Taylor & Francis
Introduction: Survivin (SVN) is a member of the inhibitor of apoptosis (IAP) protein family that
promotes cellular proliferation and inhibits apoptosis. Overexpression of SVN is associated …
promotes cellular proliferation and inhibits apoptosis. Overexpression of SVN is associated …
[HTML][HTML] Pirin is a prognostic marker of human melanoma that dampens the proliferation of malignant cells by downregulating JARID1B/KDM5B expression
C Penas, Y Arroyo-Berdugo, A Apraiz, J Rasero… - Scientific Reports, 2023 - nature.com
Originally considered to act as a transcriptional co-factor, Pirin has recently been reported to
play a role in tumorigenesis and the malignant progression of many tumors. Here, we have …
play a role in tumorigenesis and the malignant progression of many tumors. Here, we have …
Roles and signaling pathways of CITED1 in tumors: overview and novel insights
W Chen, J Jiang, J Gao, G Wang… - Journal of …, 2024 - journals.sagepub.com
CBP/p300 interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1 (CITED1)
is a transcriptional activator belonging to the non-DNA-binding transcription co-regulator …
is a transcriptional activator belonging to the non-DNA-binding transcription co-regulator …
[HTML][HTML] Knockdown of 15-bp deletion-type v-raf murine sarcoma viral oncogene homolog B1 mRNA in pancreatic ductal adenocarcinoma cells repressed cell growth …
J Song, Y Kobayashi, Y Asano, A Sato, H Taniguchi… - Cancers, 2022 - mdpi.com
Simple Summary The v-raf murine sarcoma viral oncogene homolog B1 (BRAF) gene
containing a 15-base pair (bp) deletion at L485-P490 is the cause of several cancers. We …
containing a 15-base pair (bp) deletion at L485-P490 is the cause of several cancers. We …
Minor structural changes, major functional impacts: posttranslational modifications and drug targets
HJ Kim - Archives of Pharmacal Research, 2022 - Springer
Posttranslational modifications (PTMs) are essential mechanisms that provide chemical
diversity to proteins. The additional functional and structural elements can be introduced to …
diversity to proteins. The additional functional and structural elements can be introduced to …
Recent advances in molecular targeted therapy for unresectable and metastatic BRAF-mutated melanoma
Y Kiniwa, R Okuyama - Japanese Journal of Clinical Oncology, 2021 - academic.oup.com
The clinical outcome of BRAF-mutated advanced melanoma has been improved by both
molecular targeted therapies and immune checkpoint inhibitors. Long-term follow-up data …
molecular targeted therapies and immune checkpoint inhibitors. Long-term follow-up data …
[HTML][HTML] BRAFV600E Mutant Allele Frequency (MAF) Influences Melanoma Clinicopathologic Characteristics
X Soria, F Vilardell, Ó Maiques, C Barceló, P Sisó… - Cancers, 2021 - mdpi.com
Simple Summary The mutational load of BRAFV600E in melanomas has been described as
a possible prognostic biomarker but there is no information about the mutant allele …
a possible prognostic biomarker but there is no information about the mutant allele …
Mitochondrial dysfunction and immune suppression in BRAF V600E‐mutated metastatic melanoma
N Pinto de Almeida, ÁJ Jánosi, R Hong… - Clinical and …, 2024 - Wiley Online Library
Dear Editor, Our investigation into the mitochondrial proteome dynamics in metastatic
melanoma reveals profound metabolic reprogramming that is central to the progression and …
melanoma reveals profound metabolic reprogramming that is central to the progression and …
[HTML][HTML] MGRN1 as a Phenotypic Determinant of Human Melanoma Cells and a Potential Biomarker
M Abrisqueta, S Cerdido, J Sánchez-Beltrán… - Life, 2022 - mdpi.com
Mahogunin Ring Finger 1 (MGRN1), a ubiquitin ligase expressed in melanocytes, interacts
with the α melanocyte-stimulating hormone receptor, a well-known melanoma susceptibility …
with the α melanocyte-stimulating hormone receptor, a well-known melanoma susceptibility …