The tooth provides an excellent system for deciphering the molecular mechanisms of
organogenesis, and has thus been of longstanding interest to developmental and stem cell …

Reciprocal interactions between epithelial and mesenchymal tissues play a fundamental
role in the morphogenesis of teeth and regulate all aspects of tooth development. Extensive …

Mammalian dentition consists of teeth that develop as discrete organs. From anterior to
posterior, the dentition is divided into regions of incisor, canine, premolar and molar tooth …

Teeth develop as ectodermal appendages from epithelial and mesenchymal tissues. Tooth
organogenesis is regulated by an intricate network of cell–cell signaling during all steps of …

All ectodermal organs, eg hair, teeth, and many exocrine glands, originate from two adjacent
tissue layers: the epithelium and the mesenchyme. Similar sequential and reciprocal …

Wnt/β-catenin signaling plays key roles in tooth development, but how this pathway
intersects with the complex interplay of signaling factors regulating dental morphogenesis …

Tooth agenesis or hypodontia, failure to develop all normally developing teeth, is one of the
most common developmental anomalies in man. Common forms, including third molar …

Mammalian tooth development is largely dependent on sequential and reciprocal epithelial-
mesenchymal interactions. These processes involve a series of inductive and permissive …

Odontoblasts differentiate from the cells of the dental papilla, and it has been well-
established that their differentiation in developing teeth is induced by the dental epithelium …

Teeth play essential roles in life. Their development relies on reciprocal interactions
between the ectoderm-derived dental epithelium and the underlying neural crest-originated …