Most proteins perform their biological function by interacting with themselves or other
molecules. Thus, one may obtain biological insights into protein functions, disease …

Computational protein design has a wide variety of applications. Despite its remarkable
success, designing a protein for a given structure and function is still a challenging task. On …

Accurately predicting changes in protein stability upon amino acid substitution is a much
sought after goal. Destabilizing mutations are often implicated in disease, whereas …

Highlights•Homology detection remains essential for many function prediction
methods.•Homologs found in unexpected places may reveal profound functional …

Coiled-coil protein origami (CCPO) is a modular strategy for the de novo design of
polypeptide nanostructures. CCPO folds are defined by the sequential order of …

Coiled-coil protein origami (CCPO) uses modular coiled-coil building blocks and topological
principles to design polyhedral structures distinct from those of natural globular proteins …

Abstract Tandem Repeat Proteins (TRPs) are ubiquitous in cells and are enriched in
eukaryotes. They contributed to the evolution of organism complexity, specializing for …

Kinetic stability, defined as the rate of protein unfolding, is central to determining the
functional lifetime of proteins, both in nature and in wide-ranging medical and …

可在非水相体系高效催化不对称还原反应制备手性化合物的氧化还原酶具有重要科学意义与
工业应用前景. 基于基因挖掘技术, 获得了17 个耐盐氨基酸脱氢酶的基因 …

To what degree are individual structural elements within proteins modular such that similar
structures from unrelated proteins can be interchanged? We study subdomain modularity by …