Maintaining the integrity of the gastrointestinal tract, despite the continual presence of
microbial flora and injurious agents, is essential. Epithelial continuity depends on a family of …

The present review will include the mammalian trefoil factors, TFF1, TFF2 and TFF3. It will
summarise the amino acid sequences from different species, their posttranslational …

The trefoil peptide intestinal trefoil factor (ITF) plays a critical role in the protection of colonic
mucosa and is essential to restitution after epithelial damage. These functional properties …

The human trefoil protein TFF1 is a small cysteine‐rich secreted protein that is frequently
expressed in breast tumors under the control of estrogen. The function of TFF1 in breast …

Background & Aims: Trefoil factors (TFFs) are secreted gastrointestinal proteins that have
been shown to protect and promote healing of the gastrointestinal tract. Moreover, pS2/TFF1 …

TFF peptides are involved in mucosal maintenance and repair through motogenic and
antiapoptotic activities. These peptides are overexpressed during inflammatory processes …

pS2/TFF1 trefoil factor is normally expressed in the stomach, and is found ectopically in
gastrointestinal inflammatory disorders and in various carcinomas. It is involved in stomach …

The mucosal epithelium secretes a host of protective disulfide-rich peptides, including the
trefoil factors (TFFs). The TFFs increase the viscoelasticity of the mucosa and promote cell …

The “TFF domain” is an ancient cysteine-rich shuffled module forming the basic unit for the
family of secretory TFF peptides (formerly P-domain peptides and trefoil factors). It is also an …

The solution structure of the 96-residue C-terminal fragment of the merozoite surface protein
1 (MSP-1) from Plasmodium falciparum has been determined using nuclear magnetic …