The human ether-a-go-go related gene (hERG) encodes the pore-forming subunit of the
rapid component of the delayed rectifier K+ channel, Kv11. 1, which are expressed in the …

Ion channels represent the molecular entities that give rise to the cardiac action potential,
the fundamental cellular electrical event in the heart. The concerted function of these …

Drug-induced torsades de pointes (TdP) arrhythmia is a major safety concern in the process
of drug design and development. The incidence of TdP tends to be low, so early pre-clinical …

Animals have a remarkable ability to track dynamic sensory information. For example, the
nematode Caenorhabditis elegans can locate a diacetyl odor source across a 100,000-fold …

Drug discovery and drug target identification are two intimately linked facets of intervention
strategies aimed at effectively combating pathological conditions in humans. Simple model …

The ability of an animal to locomote through its environment depends crucially on the
interplay between its active endogenous control and the physics of its interactions with the …

Blue light activation of the photoreceptor CRYPTOCHROME (CRY) evokes rapid
depolarization and increased action potential firing in a subset of circadian and arousal …

Considerable progress has been made in identifying genetic risk factors for idiosyncratic
adverse drug reactions in the past 30 years. These reactions can affect various tissues and …

PHYSICIAN scientists perform biomedical research ranging from fundamental molecular
studies to clinical trials. As such, physician scientists have a pivotal role in the biomedical …

Long-QT syndrome (LQTS) is a congenital or drug-induced change in electrical activity of
the heart that can lead to fatal arrhythmias. Mutations in 12 genes encoding ion channels …