The role of cellular senescence in female reproductive aging and the potential for senotherapeutic interventions

L Secomandi, M Borghesan, M Velarde… - Human reproduction …, 2022 - academic.oup.com
BACKGROUND Advanced maternal age is associated with decreased oocyte quantity and
quality as well as uterine and placental dysfunctions. These changes lead to infertility …

Adjuvant treatment strategies in ovarian stimulation for poor responders undergoing IVF: a systematic review and network meta-analysis

Y Zhang, C Zhang, J Shu, J Guo… - Human reproduction …, 2020 - academic.oup.com
ABSTRACT BACKGROUND Despite great advances in assisted reproductive technology,
poor ovarian response (POR) is still considered as one of the most challenging tasks in …

Antioxidants for female subfertility

MG Showell, R Mackenzie-Proctor… - … of systematic reviews, 2020 - cochranelibrary.com
Background A couple may be considered to have fertility problems if they have been trying
to conceive for over a year with no success. This may affect up to a quarter of all couples …

[HTML][HTML] Redox Regulation and Oxidative Stress in Mammalian Oocytes and Embryos Developed In Vivo and In Vitro

MLM Hardy, ML Day, MB Morris - International Journal of Environmental …, 2021 - mdpi.com
Oocytes and preimplantation embryos require careful regulation of the redox environment
for optimal development both in vivo and in vitro. Reactive oxygen species (ROS) are …

[HTML][HTML] Role of Coenzyme Q10 in Health and Disease: An Update on the Last 10 Years (2010–2020)

I Cirilli, E Damiani, PV Dludla, I Hargreaves… - Antioxidants, 2021 - mdpi.com
The present review focuses on preclinical and clinical studies conducted in the last decade
that contribute to increasing knowledge on Coenzyme Q10's role in health and disease …

[HTML][HTML] Defining low prognosis patients undergoing assisted reproductive technology: POSEIDON criteria—the why

SC Esteves, M Roque, GM Bedoschi… - Frontiers in …, 2018 - frontiersin.org
Women with impaired ovarian reserve or poor ovarian response (POR) to exogenous
gonadotropin stimulation present a challenge for reproductive specialists. The primary …

[HTML][HTML] Maternal low-grade chronic inflammation and intrauterine programming of health and disease

F Parisi, R Milazzo, VM Savasi, I Cetin - International journal of molecular …, 2021 - mdpi.com
Overweight and obesity during pregnancy have been associated with increased birth
weight, childhood obesity, and noncommunicable diseases in the offspring, leading to a …

[HTML][HTML] Understanding ovarian hypo-response to exogenous gonadotropin in ovarian stimulation and its new proposed marker—the follicle-to-oocyte (FOI) index

C Alviggi, A Conforti, SC Esteves, R Vallone… - Frontiers in …, 2018 - frontiersin.org
Hypo-responsiveness to controlled ovarian stimulation is an undervalued topic in
reproductive medicine. This phenomenon manifests as a low follicles output rate (FORT) …

[HTML][HTML] The POSEIDON criteria and its measure of success through the eyes of clinicians and embryologists

SC Esteves, C Alviggi, P Humaidan… - Frontiers in …, 2019 - frontiersin.org
This article represents a viewpoint on the POSEIDON criteria by a group of clinicians and
embryologists. Its primary objective is to contextualize the Poseidon criteria and their metric …

Update on the management of poor ovarian response in IVF: the shift from Bologna criteria to the Poseidon concept

P Drakopoulos, E Bardhi, L Boudry… - Therapeutic …, 2020 - journals.sagepub.com
Despite the considerate progress to which assisted reproduction technology (ART) has been
subject since 1978, some issues remain unresolved. Notably, the clinical management of …