The review of alpha‐linolenic acid: Sources, metabolism, and pharmacology

Q Yuan, F Xie, W Huang, M Hu, Q Yan… - Phytotherapy …, 2022 - Wiley Online Library
α‐linolenic acid (ALA, 18: 3n‐3) is a carboxylic acid composed of 18 carbon atoms and three
cis double bonds, and is an essential fatty acid indispensable to the human body. This study …

Pathophysiology of NAFLD and NASH in experimental models: the role of food intake regulating peptides

L Kořínková, V Pražienková, L Černá… - Frontiers in …, 2020 - frontiersin.org
Obesity, diabetes, insulin resistance, sedentary lifestyle, and Western diet are the key factors
underlying non-alcoholic fatty liver disease (NAFLD), one of the most common liver diseases …

Effect of linoleic acid on cholesterol levels in a high-fat diet-induced hypercholesterolemia rat model

NA Azemi, AK Azemi, L Abu-Bakar, V Sevakumaran… - Metabolites, 2022 - mdpi.com
Cardiovascular disease is the leading cause of morbidity and mortality worldwide,
accounting for almost one-third of all deaths. The risk factors for developing this disease …

Effect of ω-3 polyunsaturated fatty acids-derived bioactive lipids on metabolic disorders

J Duan, Y Song, X Zhang, C Wang - Frontiers in physiology, 2021 - frontiersin.org
Arachidonic acid (ARA) is an important ω-6 polyunsaturated fatty acid (PUFA), and
docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA) and n-3 docosapentaenoic acid …

Plant sterol ester of α-linolenic acid ameliorates high-fat diet-induced nonalcoholic fatty liver disease in mice: association with regulating mitochondrial dysfunction …

H Han, X Li, Y Guo, M Zheng, T Xue, L Wang - Food & function, 2021 - pubs.rsc.org
The present study was designed to explore the beneficial mitochondrial effects and anti-
oxidative activities of plant sterol ester of α-linolenic acid (PS-ALA) through AMP-activated …

Plant sterol ester of α-linolenic acid improved non-alcoholic fatty liver disease by attenuating endoplasmic reticulum stress-triggered apoptosis via activation of the …

H Han, T Xue, J Li, Y Guo, X Li, L Wang, L Pei… - The Journal of …, 2022 - Elsevier
Apoptosis is a feature of progressions steatosis to nonalcoholic steatohepatitis (NASH) and
can be explained by endoplasmic reticulum stress (ERS). The present study aimed to …

Vitamin D3 enhances the effects of omega‐3 oils against metabolic dysfunction‐associated fatty liver disease in rat

B Refaat, AH Abdelghany, J Ahmad, OM Abdalla… - …, 2022 - Wiley Online Library
This study investigated the effects of omega‐3 oils (OM) and/or vitamin D3 (VD) against
metabolic dysfunction‐associated fatty liver disease (MAFLD). Forty rats were divided into …

[HTML][HTML] Alfalfa leaf meal as a new protein feedstuff improves meat quality by modulating lipid metabolism and antioxidant capacity of finishing pigs

M Guo, Z Wang, Z Gao, J Ma, W Huangfu, J Niu, B Liu… - Food Chemistry: X, 2023 - Elsevier
The effects of alfalfa leaf meal (ALM) on the meat quality of finishing pigs are largely
unknown. Here, we investigated the effects of ALM diet on meat quality by replacing 0 …

DHA/EPA supplementation decreases anxiety-like behaviour, but it does not ameliorate metabolic profile in obese male rats

J Neto, J Jantsch, S de Oliveira, MF Braga… - British Journal of …, 2022 - cambridge.org
Obesity is a major public health problem that predisposes to several diseases and higher
mortality in patients with COVID-19. Obesity also generates neuroinflammation, which …

Through regulation of the SIRT1 pathway plant sterol ester of α-linolenic acid inhibits pyroptosis thereby attenuating the development of NASH in mice

H Han, J Li, L Tian, L Pei, M Zheng - The Journal of Nutritional Biochemistry, 2023 - Elsevier
Increasing evidence demonstrated that pyroptosis and subsequent inflammation played an
important role in the pathological process of non-alcoholic steatohepatitis (NASH). Plant …