Zebrafish patient avatars in cancer biology and precision cancer therapy

M Fazio, J Ablain, Y Chuan, DM Langenau… - Nature Reviews …, 2020 - nature.com
In precision oncology, two major strategies are being pursued for predicting clinically
relevant tumour behaviours, such as treatment response and emergence of drug resistance …

The resolution of inflammation: Principles and challenges

SE Headland, LV Norling - Seminars in immunology, 2015 - Elsevier
The concept that chemokines, cytokines and pro-inflammatory mediators act in a co-
ordinated fashion to drive the initiation of the inflammatory reaction is well understood. The …

A high-resolution mRNA expression time course of embryonic development in zebrafish

RJ White, JE Collins, IM Sealy, N Wali, CM Dooley… - elife, 2017 - elifesciences.org
We have produced an mRNA expression time course of zebrafish development across 18
time points from 1 cell to 5 days post-fertilisation sampling individual and pools of embryos …

Zebrafish regulatory T cells mediate organ-specific regenerative programs

SP Hui, DZ Sheng, K Sugimoto, A Gonzalez-Rajal… - Developmental cell, 2017 - cell.com
The attenuation of ancestral pro-regenerative pathways may explain why humans do not
efficiently regenerate damaged organs. Vertebrate lineages that exhibit robust regeneration …

Advances in research of fish immune-relevant genes: a comparative overview of innate and adaptive immunity in teleosts

L Zhu, L Nie, G Zhu, L Xiang, J Shao - Developmental & Comparative …, 2013 - Elsevier
Fish is considered to be an important model in comparative immunology studies because it
is a representative population of lower vertebrates serving as an essential link to early …

[HTML][HTML] The zebrafish as a model to study intestinal inflammation

S Brugman - Developmental & Comparative Immunology, 2016 - Elsevier
Starting out as a model for developmental biology, during the last decade, zebrafish have
also gained the attention of the immunologists and oncologists. Due to its small size, high …

Immune system and immune responses in fish and their role in comparative immunity study: a model for higher organisms

PR Rauta, B Nayak, S Das - Immunology letters, 2012 - Elsevier
The basal position of fish in vertebrate phylogeny makes them very attractive for genomic
and functional comparative immunity studies. Adaptive immunity arose early in vertebrate …

Toxicity of silver nanoparticles in zebrafish models

PV Asharani, YL Wu, Z Gong, S Valiyaveettil - Nanotechnology, 2008 - iopscience.iop.org
This study was initiated to enhance our insight on the health and environmental impact of
silver nanoparticles (Ag-np). Using starch and bovine serum albumin (BSA) as capping …

Identification of polarized macrophage subsets in zebrafish

M Nguyen-Chi, B Laplace-Builhe, J Travnickova… - Elife, 2015 - elifesciences.org
While the mammalian macrophage phenotypes have been intensively studied in vitro, the
dynamic of their phenotypic polarization has never been investigated in live vertebrates. We …

A transgenic zebrafish model of neutrophilic inflammation

SA Renshaw, CA Loynes, DMI Trushell, S Elworthy… - Blood, 2006 - ashpublications.org
We have established an in vivo model for genetic analysis of the inflammatory response by
generating a transgenic zebrafish line that expresses GFP under the neutrophil-specific …