Bone has a remarkable endogenous regenerative capacity that enables scarless healing
and restoration of its prior mechanical function, even under challenging conditions such as …

Mesenchymal stromal cells (MSCs) are widely used in the clinic because they involve fewer
ethical issues and safety concerns compared to other stem cells such as embryonic stem …

Clinical trials using adult stem cells to regenerate damaged heart tissue continue to this
day,, despite ongoing questions of efficacy and a lack of mechanistic understanding of the …

Cell therapy has been a promising strategy for cardiac repair after injury or infarction;
however, low retention and engraftment of transplanted cells limit potential therapeutic …

Abstract Background Extracellular vesicles (EVs) derived from bone marrow mesenchymal
stem cells (MSCs) pretreated with atorvastatin (ATV)(MSCATV-EV) have a superior cardiac …

Methyltransferase-like 3 (METTL3) is the main enzyme for N 6-methyladenosine (m 6 A)-
based methylation of RNAs and it has been implicated in many biological and …

Background Bone marrow mesenchymal stem cells (MSCs) are among the most common
cell types to be used and studied for cardiac regeneration. Low survival rate and difficult …

The lymphatic vasculature has an essential role in maintaining normal fluid balance in
tissues and modulating the inflammatory response to injury or pathogens. Disruption of …

In the past decades, numerous preclinical studies and several clinical trials have evidenced
the feasibility of cell transplantation in treating heart diseases. Over the years, different …

Elevated pro-inflammatory biomarkers and cytokines are associated with morbidity and
mortality in heart failure (HF). Preclinical and clinical studies have shown multiple …