[HTML][HTML] Advances and challenges in stem cell culture

C McKee, GR Chaudhry - Colloids and surfaces B: Biointerfaces, 2017 - Elsevier
Stem cells (SCs) hold great promise for cell therapy, tissue engineering, and regenerative
medicine as well as pharmaceutical and biotechnological applications. They have the …

Microcarriers for upscaling cultured meat production

V Bodiou, P Moutsatsou, MJ Post - Frontiers in nutrition, 2020 - frontiersin.org
Due to the considerable environmental impact and the controversial animal welfare
associated with industrial meat production, combined with the ever-increasing global …

A fully defined and scalable 3D culture system for human pluripotent stem cell expansion and differentiation

Y Lei, DV Schaffer - … of the National Academy of Sciences, 2013 - National Acad Sciences
Human pluripotent stem cells (hPSCs), including human embryonic stem cells and induced
pluripotent stem cells, are promising for numerous biomedical applications, such as cell …

[HTML][HTML] Application of human mesenchymal and pluripotent stem cell microcarrier cultures in cellular therapy: achievements and future direction

AKL Chen, S Reuveny, SKW Oh - Biotechnology advances, 2013 - Elsevier
Mesenchymal stem cells (MSCs) have recently made significant progress with multiple
clinical trials targeting modulation of immune responses, regeneration of bone, cartilage …

[HTML][HTML] Progress and challenges in large-scale expansion of human pluripotent stem cells

C Kropp, D Massai, R Zweigerdt - Process Biochemistry, 2017 - Elsevier
The constant supply of high cell numbers generated by defined, robust, and economically
viable culture processes is indispensable for the envisioned application of human …

Process engineering of human pluripotent stem cells for clinical application

M Serra, C Brito, C Correia, PM Alves - Trends in biotechnology, 2012 - cell.com
Human pluripotent stem cells (hPSCs), including embryonic and induced pluripotent stem
cells, constitute an extremely attractive tool for cell therapy. However, flexible platforms for …

Three-dimensional spheroid cell culture of umbilical cord tissue-derived mesenchymal stromal cells leads to enhanced paracrine induction of wound healing

JM Santos, SP Camões, E Filipe, M Cipriano… - Stem cell research & …, 2015 - Springer
Introduction The secretion of trophic factors by mesenchymal stromal cells has gained
increased interest given the benefits it may bring to the treatment of a variety of traumatic …

Advances in cell culture: anchorage dependence

OW Merten - … Transactions of the Royal Society B …, 2015 - royalsocietypublishing.org
Anchorage-dependent cells are of great interest for various biotechnological applications.(i)
They represent a formidable production means of viruses for vaccination purposes at very …

Suspension culture of human pluripotent stem cells in controlled, stirred bioreactors

R Olmer, A Lange, S Selzer, C Kasper… - … Engineering Part C …, 2012 - liebertpub.com
Therapeutic and industrial applications of pluripotent stem cells and their derivatives require
large cell quantities generated in defined conditions. To this end, we have translated single …

Stem cell cultivation in bioreactors

CAV Rodrigues, TG Fernandes, MM Diogo… - Biotechnology …, 2011 - Elsevier
Cell-based therapies have generated great interest in the scientific and medical
communities, and stem cells in particular are very appealing for regenerative medicine, drug …