Catalysis and Electron Transfer in De Novo Designed Metalloproteins

KJ Koebke, TBJ Pinter, WC Pitts, VL Pecoraro - Chemical reviews, 2022 - ACS Publications
One of the hallmark advances in our understanding of metalloprotein function is showcased
in our ability to design new, non-native, catalytically active protein scaffolds. This review …

Engineered repeat protein hybrids: the new horizon for biologic medicines and diagnostic tools

KB Uribe, E Guisasola, A Aires… - Accounts of Chemical …, 2021 - ACS Publications
Conspectus The last decades have witnessed unprecedented scientific breakthroughs in all
the fields of knowledge, from basic sciences to translational research, resulting in the drastic …

Allosteric cooperation in a de novo-designed two-domain protein

F Pirro, N Schmidt, J Lincoff, ZX Widel… - Proceedings of the …, 2020 - National Acad Sciences
We describe the de novo design of an allosterically regulated protein, which comprises two
tightly coupled domains. One domain is based on the DF (Due Ferri in Italian or two-iron in …

An Electroactive and Self‐Assembling Bio‐Ink, based on Protein‐Stabilized Nanoclusters and Graphene, for the Manufacture of Fully Inkjet‐Printed Paper‐Based …

A Silvestri, S Vázquez‐Díaz, G Misia, F Poletti… - Small, 2023 - Wiley Online Library
Hundreds of new electrochemical sensors are reported in literature every year. However,
only a few of them makes it to the market. Manufacturability, or rather the lack of it, is the …

Engineering Proteins for PEDOT Dispersions: A New Horizon for Highly Mixed Ionic‐Electronic Biocompatible Conducting Materials

A Dominguez‐Alfaro, N Casado, M Fernandez… - Small, 2024 - Wiley Online Library
Abstract Poly (3, 4‐ethylenedioxythiophene)(PEDOT) doped with polystyrene sulfonate
(PSS) is the most used conducting polymer from energy to biomedical applications. Despite …

White-emitting protein-metal nanocluster phosphors for highly performing biohybrid light-emitting diodes

A Aires, V Fernández-Luna, J Fernández-Cestau… - Nano Letters, 2020 - ACS Publications
This work presents a simple in situ synthesis and stabilization of fluorescent gold
nanoclusters (AuNCs) with different sizes using engineered protein scaffolds in water. The …

Diversity and features of proteins with structural repeats

EI Deryusheva, AV Machulin, OV Galzitskaya - Biophysical Reviews, 2023 - Springer
The review provides information on proteins with structural repeats, including their
classification, characteristics, functions, and relevance in disease development. It explores …

Engineering multifunctional metal/protein hybrid nanomaterials as tools for therapeutic intervention and high-sensitivity detection

A Aires, D Maestro, JR Del Rio, AR Palanca… - Chemical …, 2021 - pubs.rsc.org
Protein-based hybrid nanomaterials have recently emerged as promising platforms to
fabricate tailored multifunctional biologics for biotechnological and biomedical applications …

Protein-based functional hybrid bionanomaterials by bottom-up approaches

A Beloqui, AL Cortajarena - Current Opinion in Structural Biology, 2020 - Elsevier
Highlights•Insitu fabrication of protein-hybrid bionanomaterials leads to new materials with
defined and easily tailored architectures 'easily'tailored.•Advances in the field aim to achieve …

Engineered flavoproteins as bioorthogonal photo-triggers for the activation of metal-based anticancer prodrugs

LF Mazzei, J Gurruchaga-Pereda, Á Martínez… - Chemical …, 2023 - pubs.rsc.org
A multifunctional hybrid constructed for controlling the delivery and activation of Pt
anticancer agents in vitro is described herein. We employed consensus tetratricopeptide …